Registration Dossier
Registration Dossier
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EC number: 279-767-0 | CAS number: 81457-65-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is considered to be too large and too insoluble for systemic uptake.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Solvent Blue 67 consists of several coloured isomers which all have a molecular weight of more than 1000 g/mol. The isomers share the copper phthalocyanine core and differ in the number and position of the 3-isopropoxypropylamine substituents. The highest content of ca 65% is formed by CuPC species with four substituents having a molecular weight of 1293.04 g/mol.
The high molecular weights are above 1000 g/mol which is a generally accepted threshold for systemic uptake. In addition, the solubility in water is very low (0.008 mg/L), indicating that transport in aqueous systems is very poor. The solubility in octanol is comparatively good (2g/L), so solubility in fat is also expected to be good. Experience with low molecular weight solvent dyes shows that systemic uptake can be visualised at necropsy via colouring of the tissues. In this case, no bluish discoloration of any organ or fat tissue was observed at the end of the OECD 422 study (BASF 2013). This study was performed with doses of 100, 300 and 1000 mg/kg bw applied in form of an aqueous suspension. Also no discoloration of dam milk of pup stomach content was noted.
Considering the overall data, Solvent Blue 67 is not expected to be taken up after ingestion.
No experimental data is available for the dermal route of exposure. A default skin permeability of 10% can be assumed according to ECHA guidance if the molecular weight is higher than 500 g/mol and the log Pow is higher than 4. These criteria are fulfilled. Considering the molecular weight of > 1000 g/mol and the very poor solubility in water, skin permeability is considered to be negligible.
No experimental data is available for the inhalation route. The substance is considered to behave like an inert nuisance dust. It is not volalite and exposure could only occur via dusty material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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