Registration Dossier
Registration Dossier
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EC number: 213-986-4 | CAS number: 1071-22-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature (IUCLID 2000 data set). The original reference was not available for review and no further information is available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-(trichlorosilyl)propiononitrile
- EC Number:
- 213-986-4
- EC Name:
- 3-(trichlorosilyl)propiononitrile
- Cas Number:
- 1071-22-3
- Molecular formula:
- C3H4Cl3NSi
- IUPAC Name:
- 3-(trichlorosilyl)propanenitrile
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Concentration: 0.5 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: overall result
- Remarks on result:
- other: 0.5 mg caused severe irritation
Applicant's summary and conclusion
- Conclusions:
- In a very limited summary of an eye irritation study in IUCLID 2000 (reliaility score 4), 0.5 mg of 3-(trichlorosilyl)propiononitrile caused severe irritation in rabbits.
- Executive summary:
In a very limited summary of an eye irritation study in IUCLID 2000 (reliability score 4), 0.5 mg of 3-(trichlorosilyl)propiononitrile caused severe irritation in rabbits. No further details are available.
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