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EC number: 604-569-1 | CAS number: 147126-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.11.2004 to 02.12.2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate
- EC Number:
- 604-569-1
- Cas Number:
- 147126-62-3
- Molecular formula:
- C14H24O4S
- IUPAC Name:
- (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate
- Reference substance name:
- OS Menthol Ester
- IUPAC Name:
- OS Menthol Ester
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Controls: medium only
- Evidence of undissolved material: Although OS MENTHOL ESTER is reported tobe insoluble in water the water-accommodated fraction (WAF) of the saturated stock suspension mixture of test item and dilution water was used for testing
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (Straus)
- Method of breeding: Culturing and holding of the test species was conducted at the Stantec Labaratory (Guelph, ON), according to the Stantec SOP #230
(Stantec, 2004a). Daphnia cultures were maintained in 1 L polystyrene containers containing 900 mL of Stantec's Iabaratory dilution water (groundwater).
Culture temperature and photoperiod were identical to that of the test system (temperature 20 +- 2°C and a photoperiod of 16 hours light and 8 hours of darkness with a 30-minute transition period). Neonae test organisms were obtained from the stock cultures following the daily transfer of adult daphnids, to ensure that test organisms were of a uniform age, and less than 24 hours old.
- Feeding during test
- Foodtype: Two to four-week old adult daphnids were transferred to fresh water daily, andfed a 3:1 mixture of Selenastrum capricomutum and Chlorella
fusca (green algae) at a rate of 10 mUL (density of 3.5 X 107 cellslmL).
- Amount: The algal diet was supplemented with a suspension of YCT (yeast, Cerophyll, and commercial traut pellets ), fed daily at a rate of 5 mUL.
- Frequency: daily
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 220 ± 20 mg/L as CaCO3
- Nominal and measured concentrations:
- nominal: 1 030 mg/L, 473.6 mg/L, 217.9 mg/L, 100.2 mg/L, 46.1 mg/L, 21.2mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: all glass test aquaria of 250 mL volume filled
- Aeration: no
- No. of vessels per concentration (replicates): 4 (4)
- No. of vessels per control (replicates): 4 (4)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Ground water
- Total organic carbon: < 0.5 mg/L
- Alkalinity: 236 mg/L
- Ca/Mg ratio: 61.4 mg Ca/L, 29.1 mg Mg/L
- Conductivity: 522 µS/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: Dissolved oxygen, pH, conductivity at start and end oftest, temperature and visual observations at 0, 24 and 48
hours, dilution water hardness at 0-hours.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: light/dark cycle was 16 to 8 h
- Light intensity: 400 to 800 LUX
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): immobilisation was monitored one and two days after exposure - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 87.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: all daphnids were mobile in the control during the 2 days of exposure.
- Any observations that might cause a difference between measured and nominal values: the test substance was insoluble in medium, the test concentrations were present as a clear solution - Results with reference substance (positive control):
- Results with reference substance
- Results with reference substance valid? yes
- EC50/LC50: LC50 = 5.6 mg/L
Any other information on results incl. tables
exposure period 0h | exposure period 24h | exposure period 48h | ||||||||||
Immobility (per vessel) | a | b | c | d | a | b | c | d | a | b | c | d |
Nominal conc. of test substance (mg/L) | ||||||||||||
0 (control) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
21.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
46.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
100.2 | 0 | 0 | 0 | 0 | 1 | 2 | 4 | 1 | 3 | 4 | 4 | 2 |
217.9 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 2 | 5 | 2 | 2 | 5 |
473.6 | 0 | 0 | 0 | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
1030 | 0 | 0 | 0 | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
Applicant's summary and conclusion
- Conclusions:
- In this short-term toxicity study in daphnia magna an 48h EC50 value of 87.3 mg/L was found.
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