Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 480-070-0 | CAS number: 85-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-12-15 to 2004-01-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted 2001-12-17
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2003-06-04
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 480-070-0
- EC Name:
- -
- Cas Number:
- 85-27-8
- Molecular formula:
- C14H14O2
- IUPAC Name:
- 4-(1-phenylethyl)benzene-1,3-diol
- Details on test material:
- - Name of test material (as cited in study report): BIO 377
- Chemical name: 1,3-Benzenediol, 4-(1-phenylethyl)-
- Physical state: clear viscous to solid
- Storage condition of test material: cool, dry, dark
- Solubility: 50 % in Mygliol (nautral oil) = well soluble; 50 % in peanut oil (conditionally soluble); 20 % in peanut oil (well soluble)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - SPF Wistar rats of the stock Shoe:WIST
- Source: DIMED Schönwalde GmbH, D-16352 Schönwalde
- Weight at study initiation: 129 g - 165 g
- Fasting period before study: rats were fasted overnight prior to dosing. After dosing diet was withheld for 4 more hours.
- Housing: the rats were kept in transparent polycarbonate cages (macrolone type III, floor area 810 cm^2) with two or three in each cage. The cages were cleaned and the bedding changed at least twice a week. Bedding was pinewood sawdust "Lignocel-Fasern" from Altromin, D-32791 Lage, Lippe.
- Diet (ad libitum): a pelleted complete rodent diet "Altromin 1314" from Altromin GmbH, D-32791 Lage, Lippe
- Water (ad libitum): domestic quality drinking water acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth.
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS- the study took place ina room provided with filtered air.
- Temperature: 21 °C +/- 3 °C
- Relative humidity: 55 % +/- 15 %
- Air changes: 10 times/hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
DOSAGE PREPARATION: peanut oil was used as the vehicle for the preparation of the test item. For this the test item was initially liquefied by heavy warming up to approx. 80 - 90 °C and afterwards mixed with peanut oil to an applicable solution with a temperature of about 37 °C. - Doses:
- 2000 mg/kg bw and 300 mg/kg bw
- No. of animals per sex per dose:
- 2000 mg/kg bw: 3 females
300 mg/kg bw: 6 females (divided in two groups of three) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: each rat was observed 30 min, 2, 4 and 6 hours after the administration and thereafter daily for a period of 14 consecutive days. Body weight (b.w.) was recorded on days 0, 7 and 14.
- Necropsy of survivors performed: yes, all rats were killed by inhalation of CO2 on day 14 and subjected to a gross necropsy examination.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals of the 2000 mg/kg bw dose level died. Death occurred by day 1.
None of the animals at the 300 mg/kg bw dose level died. - Clinical signs:
- other: All animals of the 2000 mg/kg bw dose level showed a severe intoxication and died on account of the treatment. None of the animals at the 300 mg/kg bw dose level showed severe signs of toxicosis. 2000 mg/kg bw: All animals showed a hunched posture and pi
- Gross pathology:
- The necropsy revealed the following pathological abnormalities:
2000 mg/kg bw: the rigor mortis had already begun. Furthermore a distended gastrointestinal tract with bleeding of the stomach and intestinal mucosa as well as residues of feed in the stomach were revealed.
300 mg/kg bw: one animal showed a liquid stomach content and petechial bleeding of the stomach wall. No pathological abnormalities were observed in the remaining animals.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 in female rats was found to be below 2000 mg/kg bw and above 300 mg/kg bw (LD50 cut-off mg/kg bw: 500 mg/kg bw).
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, the test substance is classified as harmful if swallowed.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is classified as Category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.