Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-420-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment of the toxicokinetic properties based on the physico-chemical properties of the test substance and the results of toxicity studies.
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment of the toxicokinetic properties based on the physico-chemical properties of the test substance and the results of toxicity studies.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Expert statement
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Assessment of the toxicokinetic properties based on the results obtained for the toxicological end-points with simultaneous reference to physico-chemical data such as solubility in various solvents and log Pow
- GLP compliance:
- no
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): H112323
- Physical state: Dark blue powder
Constituent 1
Test animals
- Species:
- other: Not applicable
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable
Administration / exposure
- Route of administration:
- other: Not applicable
- Vehicle:
- other: Not applicable
- Details on exposure:
- Not applicable
- Duration and frequency of treatment / exposure:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable
- No. of animals per sex per dose / concentration:
- Not applicable
- Control animals:
- other: Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
- Preliminary studies:
- None
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Absorption from the GI tract would be anticipated to be slow. There are indications of a non-absorbed proportion of the dose being passed through the gut, commensurate with the postulated low GI permeability of test substance.
- Type:
- distribution
- Results:
- Distributed widely to a number of tissues including skin. At lower doses, distributed only to stomach (site of administration)
- Type:
- excretion
- Results:
- via kidneys. No conclusions can be drawn regarding biliary excretion as excreted and unabsorbed compound would both appear in faeces
- Type:
- metabolism
- Results:
- No information is available on potential metabolism of test substance.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- No data
- Details on distribution in tissues:
- No data
- Details on excretion:
- No data
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable
Any other information on results incl. tables
Evaluation and Assessment:
ABSORPTION
Based on the repeat dose oral study it would appear that some test substance was absorbed from rat intestine. Observations of black faeces are indicative of a non-absorbed proportion of the dose being passed through the gut, commensurate with the postulated low GI permeability of the compound. The amount of absorption was apparently dose related in that the level of Hl12323-staining of tissues was greatest with the highest dose level. Based on the repeat dose oral study it would appear that some test substance was absorbed from rat intestine. Observations of black faeces are indicative of a non-absorbed proportion of the dose being passed through the gut, commensurate with the postulated low GI permeability of the compound. The amount of absorption was apparently dose related in that the level of test substance staining of tissues was greatest with the highest dose level.
DISTRIBUTION
Based on appearance of dye in tissues it would appear that the compound was distributed widely to a number of tissues including skin. At lower doses staining was only observed in the stomach (site of administration) and the kidney suggesting that the kidney is involved in excretion of test substance.
METABOLISM
No information is available on potential metabolism of test substance. In the AMES tests the same minor effects were observed both in the presence and absence of 59.
EXCRETION
Following high doses of test substance a coloured compound, presumably parent, was excreted in urine. No conclusions can be drawn regarding biliary excretion as excreted and unabsorbed compound would both appear in faeces.
Compound was eliminated gradually. Nine to 10 d following the final dose no coloration of urine was observed. By Day 43 (15 d post-final dose) in all but 2 rats the skin discoloration had disappeared indicative of compound clearance from the animals.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: does not show any toxicokinetic peculiarity
Test substance is only absorbed to a limited extent following oral dosing. It is distributed to a number of tissues and excreted gradually from the body. Most of the discolouration of tissues has disappeared within 15 d post dose. A coloured compound, presumably parent, is excreted in urine. - Executive summary:
Assessment of the toxicokinetic properties of the test substance was carried out based on the results obtained for the toxicological end-points with simultaneous reference to physico-chemical data.
Test substance is only absorbed to a limited extent following oral dosing. It is distributed to a number of tissues and excreted gradually from the body. Most of the discolouration of tissues has disappeared within 15 d post dose. A coloured compound, presumably parent, is excreted in urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deși ECHA oferă o varietate bogată de materiale online în limba dumneavoastră, o parte din conţinutul acestei pagini este disponibil numai în limba engleză. Pentru mai multe informaţii referitoare la practica multilingvă a ECHA.
Bun venit pe site-ul ECHA. Acest site nu este deplin acceptat în Internet Explorer 7 (și versiuni anterioare). Vă rugăm să vă actualizați versiunea de Internet Explorer.
Acest site folosește module cookie pentru a garanta că aveți parte de cea mai bună experiență pe paginile noastre.
Aflați mai multe despre cum folosim modulele cookie.