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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);
Reference Type:
review article or handbook
Title:
No information
Author:
Lenga, R. E. (Ed.)
Year:
1988
Bibliographic source:
The Sigma-Aldrich Library of Chemical Safety Data 2nd ed., 1988, 1, 1349, Sigma-Aldrich, Milwaukee, WI, USA.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
DOSE database study report
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-xylidine
EC Number:
202-437-4
EC Name:
3,4-xylidine
Cas Number:
95-64-7
Molecular formula:
C8H11N
IUPAC Name:
3,4-dimethylaniline

Test animals

Species:
other: un specified
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Vapour or mist irritating to the skin mucous membranes and upper respiratory tract

Applicant's summary and conclusion

Executive summary:

Vapour or mist is irritating to the skin mucous membranes and upper respiratory tract (species unspecified).