Registration Dossier
Registration Dossier
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EC number: 266-104-5 | CAS number: 66069-34-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The information used is from a document which summarises many investigations on the substance potassium clavulanate, the document looks into the toxicity of potassium clavulanate in a range of different species by both oral and parenteral routes. The document reviews the results of many study reports and very little information regarding the methods has been included, which is why a klimisch reliability of 4 has been given.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- potassium clavulanate
- IUPAC Name:
- potassium clavulanate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 3000 - 5000 mg/kg
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 - 5 000 other: mg/kg
- Based on:
- not specified
- Remarks on result:
- other: Collapse and convulsions followed by death.
- Mortality:
- Intravenous dosing in mice resulted in collapse and convulsions followed by death.
Applicant's summary and conclusion
- Conclusions:
- Intravenous dosing in mice resulted in collapse and convulsions followed by death at 3000 - 5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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