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EC number: 206-556-2 | CAS number: 354-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study report was not formally finalized because the laboratory activities were stopped shortly after finalization of the experimental phase.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Trifluoroacetyl chloride
- EC Number:
- 206-556-2
- EC Name:
- Trifluoroacetyl chloride
- Cas Number:
- 354-32-5
- Molecular formula:
- C2ClF3O
- IUPAC Name:
- trifluoroacetyl chloride
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were inspected for signs of illness at the beginning of the acclimatization period. No abnormalities were detected. 20 male and 20 female rats were used. Except during their stay in the exposure chamber the animals had free access to food and water. Animal room condition: 22°C, 30-70% relative humidity, 12 hour light/12 hour dark, ventilation frequency 16 times/hour, hygienic procedures according to standart operating procedure.
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- During exposure the concentration of test material, the possible degradation products were measured on-line by infrared analysis. Concentrations were calculated on-line by Fourier Transform-Infrared analysis of multicomponent gas mixtures.
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 40 and 90 ppm
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The purpose of this study was to compare the toxic potential of two batches of different production process of TFAC in rats and to confirm the LC 50 (78ppm). 20 male and 20 felmales Sprague Dawley derived rats were randomly distributed in groups of 5 and exposed once for 4h via inhalation to TFAC. Target concentrations for both batches were 40 and 90 ppm. The animals were exposed in a cylindrical nose-only exposure chamber of polypropylene. After termination of exposure the animals were observed for 14 days. During this period the animals were observed for clinical symptoms and changes in body weights. All animals were necropsied. The animals were examined for changes of their external appearance and for macroscopical changes in the cervical area and the abdominal and thoracic cavities. The lungs (including the tracheas) were weighed.
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 78 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- other: mortality
- Effect level:
- ca. 40 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 1/10 male and 1/10 female were found dead at 2 and 3 days after exposure
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- ca. 90 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 8/10 male and 8/10 female were found dead between 1 and 6 days after exposure.
- Mortality:
- The mortalities were observed within the first week after exposure.
At 40 ppm: no mortality in the group E (TFAC from process 2); 2 mortalities for the group A (TFAC from process 1)
At 90 ppm: 4 males and 4 females died in the group B (TFAC from process 1); 4 males and 4 females died in the group D (TFAC from process 2). - Clinical signs:
- other: All observed clinical signs are reported in the section " any other information on results" below.
- Body weight:
- All animals showed a marked body weight loss during the first 3 days. At the end of the observation period the weight gains of the survivors resumed up to normal values except for the animals exposed to 90 ppm TFAC of process 2 which showed a lower body weight gain.
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
All observed clinical signs
Group A (40 ppm, process 1), males: 1h post-exposure: apathy (animal 1), slight respiratory difficulties (animals 2,3,7,8), slight reduced respiratoty rates and alertness (all males), severe ptosis (all males), reduced fear reaction and locomotor activity (animals 3 and 7), severe reduced fear reaction (animals 3 and 8), abnormal body posture (animals 2 and 8). 1 day post-exposure: apathy, slight respiratory difficulties, severe reduced fear reaction, locomotor activity, slight piloerection (all animals), abnormal body posture (animals 2 and 8), ptosis (animals 2 and 8). 2 days post-exposure: slighty reduced respiratory rates, alertness, fear reaction and locomotor activity (all males), and ptosis (animal 1), abnormal body posture (animal 4 and 10) 3 days post-exposure: severe tremors (no. 1), slight respiratory difficulties, slight increased respiratory rates (all animals), abnormal body gate (no. 1) 5 days post-exposure: slight stereotypic behaviour (no. 3), slightly reduced alertness, fear reaction and locomotor activity (all males), and ptosis (no. 3 and 7), abnormal body posture (no. 4) 6 days post-exposure: slight abnormal posture (no. 6) 7 days post-exposure: slightly reduced fear reaction and slight ptosis (No. 3 and 7), slightly increased respiratory rate (No. 2,4 and 6), abnormal body posture (no. 2), slight vocalization (no. 6)
Group B (90 ppm, process 1) males: 1h post-exposure: respiratory difficulties (no. 17), decreased alertness (no. 15), decreased locomotor activity (no. 11), abnormal body gait (no. 15), ptosis (no. 14, 17, 18, 19, 12), vocalization (no. 19), abnormal gait (no. 12, 14) 1 day post-exposure: respiratory difficulties (all amles), decreased fear reaction (no. 17), decreased locomotor activity (no. 17), abnoramal gait (no. 17, 15, 19 and all females), ptosis (no. 13) 2 days post-exposure: respiratory difficulties (no. 11, 19, 13 and all females), increased respiratory rates (no. 13, 11, 19 and all females) 3 days post-exposure: respiratory difficulties (no. 13 and 19). 4 days post-exposure: increased respiratory rate (no. 19), decreased fear reaction and locomotor activity (no. 13, 19), abnormal body gait (no. 19). 5 days post-exposure: decreased fear reaction (no. 13, 19, 20), decreased locomotor activity (no. 13), abnormal body gate (no. 19). 6 days post-exposure: decreased fear reaction and decreased locomotor activity (no. 13), abnormal body posture and ptosis (no. 20). The urine of animal 19 contained blood.
Group D (90 ppm, process 2), males: 1h post-exposure: respiratory difficulties (no. 31, 37, 38, 39), decreased fear reaction (no. 36, 37, 39), decreased locomotor activity (no. 31, 33, 36, 37, 38, 39, 40), abnormal body posture (no. 31, 33, 36, 38, 39, 40). 1 day post-exposure: tremors (no. 36, 40), respiratory difficulties (no. 35, 31, 33, 37, 39 and all females), increased respiratory rates (no. 35, 31, 33, 37, 39), ptosis (left eye only, no. 39). 2 days post-exposure: respiratory difficulties ( all animals), increased respiratory rates (all animals), ptosis (no. 31). 3 days post-exposure: abnormal body posture (no. 39), ptosis (no. 39), apathy (no. 40), stereotypic behaviour, respiratory difficulties, increased respiratory rates, straub tail and ptosis (no. 40). 4 days post exposure: increased respiratory rates (no. 39, 40), abnormal body posture (no. 39), piloerection (no. 39, 40), reduced locomotor activity (no. 40). 5 days post-exposure: increased respiratory rates (no. 39, 40), abnormal body posture and piloerection (no. 39).
Group E (40 ppm, process 2) males: 1h post-exposure: respiratory difficulties (no. 43, 45, 50), reduced fear reaction (no. 42, 46, 49), abnormal gait (no. 42, 43, 45, 46, 47, 48, 50), ptosis (no. 43, 45), noisy breathing (no. 45), abnormal posture (no. 46). 1 day post-exposure: ptosis (no. 12 and 46). 2 days post-exposure: increased respiratory rates (no. 49), reduced fear reaction (no. 42, 46, 49), reduced locomotor activity (no. 45, 49), abnormal body posture (no. 42, 45, 46, 49), piloerection (no. 45), ptosis (all males and no. 42, 46), vocalization (no. 41). 3 days post-exposure: abnormal gait (no. 47), piloerection (no. 45, 47, 49), abnormal body posture (no. 42), urine incontinence (no. 46, 48, 50). 8 days post-exposure: vocalization (no. 48,50)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The 4-hour LC50 of Trifluoroacetyl chloride was considered to be between 40 and 90 ppm.
- Executive summary:
The acute inhalation toxicity of trifluoroacetyl chloride (TFAC) in the rat was investigated in a GLP study similar to OECD Testing Guideline 403. The objective of this study was to compare the toxicity potential of two batches of different production process of Trifluoroacetyl chloride in rats (i.e. a technical grade and a high purity grade). Five males and five females Sprague Dawley rats were exposed per concentration and per batch for 4 hours via inhalation to Trifluoroacetyl chloride. Target concentrations for both batches were 40 and 90 ppm. The animals were exposed in a cylindrical nose-only exposure chamber of polypropylene. After termination of exposure the animals were observed for 14 days for clinical symptoms and changes in body weights. All surviving animals were necropsied and examined.
Mortalities were observed within the first week after exposure. At 40 ppm, no mortality was observed in the group exposed to the high purity grade of product, whereas 2 mortalities were observed for the technical grade product. At 90 ppm 4 males and 4 females died in both groups. All animals showed a marked body weight loss during the first 3 days. At the end of the observation period the weight gains of the survivors resumed up to normal values except for the animals exposed to 90 ppm of high purity grade product which showed a lower body weight gain. ln the animals that died within three days after exposure, the macroscopic findings included changes in the respiratory tract (oedema, emphysema) together with increases in lung weights. Haemorrhagic spots were observed on the surface of the kidneys in the one animal found dead at day 6. At the end of the 14-day observation period, increased lung weights were observed in the males exposed to product of both groups and in the females exposed to high purity grade product group. Whether this increase was sequelae of sublethal pulmonary oedema or resulting from tissue repair reaction was not established. No macroscopic observations were made in the survivors at terminal necropsy. The slope of the concentration mortality relationship is very steep. The difference between both groups (no mortality versus 2/10 fatalities at 40 ppm and equal mortality at 90 ppm) is regarded as not significant. ln addition, the slight effects on respiratory rates do not permit to distinguish a difference between the technical grade and the high purity grade products. The 4-hour LC50 of Trifluoroacetyl chloride was therefore considered to be between 40 and 90 ppm for both groups, resulting in the classification as fatal if inhaled (Category 1).
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