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Diss Factsheets
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EC number: 932-051-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-09-06 to 1989-09-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction product of Benzenesulfonic acid, C10-13-alkyl derivs and toluenesulfonic acid and sodium hydroxide
- IUPAC Name:
- Reaction product of Benzenesulfonic acid, C10-13-alkyl derivs and toluenesulfonic acid and sodium hydroxide
- Details on test material:
- - Name of test material (as cited in study report): Marlon ARL (Reaction product of Benzenesulfonic acid, C10-13-alkyl derivs and toluenesulfonic acid and sodium hydroxide)
- Physical state: solid (powder)
- Date of production: 1987-03-24
pH (20 g/L): 8 - 10
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: not mentioned
- Weight at study initiation: 116 g (mean weight)
- Fasting period before study: 16 hours
- Housing: 1 - 5 animals in Makrolon cages, type III
- Diet (e.g. ad libitum): R10 Complete feed for rats ad libitum, supplied by Ssniff Spezialfutter GmbH, Soest, Germany
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: 4 - 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 12.5 - 25.1 %
- Amount of vehicle (if gavage): 10 cm³/kg
MAXIMUM DOSE VOLUME APPLIED: 10 cm³/kg
DOSAGE PREPARATION (if unusual): The test substance was suspended in maize oil by Ultra-Turrax. - Doses:
- 1250; 1580; 1990; 2510 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Examination of clinical signs up to 6 hours after the treatment and daily observations thereafter; bodyweights were determined before treatment, and 1, 7 and 14 days after treatment.
- Necropsy of survivors performed: yes
- Other examinations performed: no - Statistics:
- The means of the body weights were calculated.
The LD50 was determined according to Litchfield and Wilcoxon and reported with 95% confidence limits (J. Pharmacol. Exp. Ther. 96, 1949, 99)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 240 mg/kg bw
- Mortality:
- 1250 mg/kg bw: male/female: 0/5
1580 mg/kg bw: male/female: 1/5
1990 mg/kg bw: male/female: 1/5
2510 mg/kg bw: male 4/5; female: 3/5 - Clinical signs:
- other: Body weight gain was nearly normal. 30 - 60 minutes after exposure the animals showed piloerection and squatting position, later diarrhea, diurese, slight sedation, ataxie, dark eyes, in part loss of weight, gain of motility, hypothermie, some times abdom
- Gross pathology:
- Sections post mortem showed hyperemie of the gastrointestinal tract mucosa, slight erosion of the stomach mucosa, congestion spleen and in part hyperemie of the renal pelvis. Sections at the end of the study showed in some animals hyperemie of the small intestine mucosa, thickening and conglutinations of the forestomach mucosa, adhesions and conglutinations of the intraabdominal organs and the peritoneum and the diaphragm, 2 animals also had grey-coloured livers and ulceration in the centrum of the conglutinations.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In an acute orale gavage study on rats according to OECD guideline 401 with Reaction product of Benzenesulfonic acid, C10-13-alkyl derivs and toluenesulfonic acid and sodium hydroxide the estimated LD50 was 2240 mg/kg bw.
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