Registration Dossier
Registration Dossier
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EC number: 801-093-8 | CAS number: 1315251-11-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a lipid normalised BCF value of 513 L/kg at 0.0362 mg/L as determined in a reliable OECD TG 305 study.
Key value for chemical safety assessment
- BCF (aquatic species):
- 513 L/kg ww
Additional information
An OECD TG 305 study in compliance with GLP criteria with Bluegill sunfish (Lepomis macrochirus) is available for the substance. Fish (125/concentration) were exposed to nominal concentrations of 0 (vehicle control), 0.004 and 0.04 mg/L of 14C-labelled the substance under flow-through conditions for 21 days (uptake phase) and followed by 14 days depuration phase. The test concentrations were analytically verified by measuring both total radioactive residue (TRR) and parent substance using GC and were determined as < MQL (vehicle control), 0.00350 and 0.0362 mg/L. Test condition was maintained at 21.5 - 22 ºC and pH 8.1 - 8.5 . The dissolved oxygen concentration was 85 - 101% of saturation value throughout the test. Fish were sampled to measure the concentration of the 14C-labelled test substance as TRR in their tissue. Results: Whole body 14C-residue concentrations reached steady-state equilibrium by 21 days of uptake. The steady state BCF (BCFss) was estimated from the ratio of the steady-state concentration in fish to that in water. The whole fish BCFss was calculated to be 677 L/kg for the low concentration treatment and 884 L/kg for the high concentration treatment. Based on the ratio of the uptake and depuration rate constants (k1 and k2 respectively) the kinetic BCF (BCFk) was estimated at 615 L/kg for the low concentration treatment and 824 L/kg for the high concentration treatment. After lipid normalisation to 5% lipid content, the whole fish BCFk values were 359 L/kg for the low concentration treatment and 513 L/kg for the high concentration treatment. The latter will be used for the risk assessment. The calculated times to 95% depuration of the C14 residue in whole fish tissue were 2.4 and 3.6 days in the low and high treatment groups, respectively.
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