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EC number: 258-508-5 | CAS number: 53378-51-1
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.06.2012-22.08.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- yes
- Remarks:
- Remark: the test solution contains NaOH due to the production method.
- Principles of method if other than guideline:
- The OECD Guideline 112 covers pure substances.
The sample tested contains different impurities and also NaOH as a stabilizer - GLP compliance:
- no
- Specific details on test material used for the study:
- The production method yields the substance in an approximately 50% aqueous solution with a content of sodium hydroxide. A sample of this has been dehydrated in order to perform the test.
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- > 8.24 - <= 8.26
- Temp.:
- 19.9 °C
- Remarks on result:
- other: Measured on a sample including impurities
- Conclusions:
- The dissociation constant pKa at 19.8ºC is 8.25 ± 0.010
The sample tested contains different impurities and also NaOH as a stabilizer, this could have an impact on the test result. - Executive summary:
The OECD Guideline 112 covers pure substances.
The sample tested contains different impurities and also NaOH as a stabilizer, this could have an impact on the test result.
Reference
Description of key information
The dissociation constant pKa at 19.8ºC is 8.25 ± 0.010
The sample tested contains different impurities and also NaOH as a stabilizer
Key value for chemical safety assessment
- pKa at 20°C:
- 8.25
Additional information
Dehydrated sample of IBP1-Na (produced by adding aqueous NaOH to IBP-1)
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