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EC number: 279-317-3 | CAS number: 79828-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Principles of method if other than guideline:
- None
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- EC Number:
- 279-317-3
- EC Name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- Cas Number:
- 79828-43-6
- Molecular formula:
- C38H18Cl2CrN16O20S4.5Na
- IUPAC Name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- None
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animal: Rat, KFM-Han, Wistar (outbred, SPF-quality);
Source: Kleintierfarm Madoerin AG, CH 4414 Fuellinsdorf/Switzerlan;
Number of animals: 5 males and 5 females; Total number: 10 males and 10 females;
Age of start of treatment: 9-11 weeks;
Body weight at start of the treatment: males:203-240g and female: 181-212 g.
Identification: by unique cage number and corresponding color-coded spots;
Randomization: randomly selected at time of delivery in groups of five.
Acclimation: at least one week under laboratory conditions, after veterinary examination.
Environmental conditions: Standard laboratory conditions: air-conditioned with 10-15 air changes per hour, and hourly monitored environment with temperature 22±3 °C, relative humidity 40-70 %, 12 hours artificial fluorescent light/12 hours dark, music/light period.
Accommodation: Group of five in Makrolon type-3 cages with standard softwood bedding. The cages were cleaned twice weekly during the test period.
Diet: Pelleted standard Kliba 343, batch 36/85 rat maintenance diet available ad libitum.
Water: community tap water from Itingen, available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- The animals received the test article on a mg/kg body weight base by oral gavage after being fasted for 12 to 18 hours (access to water was not interrupted). Food was again presented approximately one hour after dosing.
- Doses:
- 20 ml at 3000 mg/kg bw (group 1) and 5000 mg/kg (group 2) bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- FAT 40210/A was administered to rats of both sexes (5 male and 5 female for each group) by oral gavage at doses of 3000 and 5000 mg/kg bw and death rate, symptoms and necropsy were observed and the acute oral toxicity of FAT 40210 was estimated.
- Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0 % at 3000 mg/kg bw and 10 % at 5000 mg/kg bw
- Clinical signs:
- other: 3000 mg/kg bw: sedation, dyspnoea, curved body position, ruffled fur, extremities blue to black discoloured. 5000 mg/kg bw: sedation, dyspnoea, ataxia, curved body position, ruffled fur, extremities blue to black discoloured. The rats had recovered from t
- Gross pathology:
- 3000 mg/kg bw - killed: Stomach: partly blue discoloured (10); Kidneys/skin: dark-blue discoloured (5), blue discoloured (5);
5000 mg/kg bw - dead: Lung: blue discoloured, slight (1); Stomach/Intestines: blue to black discoloured, severe (1); adipose tissure: blue discoloured, slight (1);
5000 mg/kg bw- males: Stomach: blue discoloured (9); Intestines: blue discoloured slight (9); Urinary bladder, kidneys, skin: blue discoloured (9). Testis: blue discoloured (4); Uterus: blue discoloured (5).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity of FAT 40210/A in rats of both sexed, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg bw.
- Executive summary:
A key study was performed to determine the oral acute toxicity in rats according to OECD Guideline 401 (Acute Oral Toxicity).
The test article FAT 40210/A was administered to rats of both sexes by oral gavage, at doses from 3000 to 5000 mg/kg bw. The following death rate was observed: 0 % at 3000 mg/kg bw and 10 % at 5000 mg/kg bw. The LOGIT-Model could not be applied to these data. And the acute oral toxicity of FAT 40210/A in rats of both sexed, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg bw, which shall not be classified according to CLP Regulation (Regulation [EC] No. 1272/2008).
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