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EC number: 277-242-0 | CAS number: 73037-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Disodium oxybis[methylbenzenesulphonate]
- EC Number:
- 277-242-0
- EC Name:
- Disodium oxybis[methylbenzenesulphonate]
- Cas Number:
- 73037-34-0
- Molecular formula:
- C14H12Na2O7S2
- IUPAC Name:
- disodium oxybis(methylbenzenesulfonate)
- Test material form:
- solid
- Details on test material:
- Active content reported: 90-95 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8-12 weeks
- Weight at study initiation: step 1/animals no.1-3: 177-181 g, step 2/animals no 4-6: 178-183 g
- Fasting period before study: 16-19 hours
- Housing: in groups
- Diet ad libitum
- Water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sterile water
- Details on oral exposure:
- The test item was administered at a single dose by gavage using a feeding tube.
The test item was administered at a dose volume of 10 mg/ kg bw.
All animals were observed for 14 days after dosing for general clinical signs, morbidity and mortality. - Doses:
- The starting dose was selected to be 2000 mg/kg bw. ( step 1 and step 2).
As no animal died no further testing is required. - No. of animals per sex per dose:
- 3 females in each step
- Control animals:
- no
- Details on study design:
- The test item was administered at a single dose by gavage using a feeding tube to 3 female rats in each step.
The test item was administered at a dose volume of 10 mg/ kg bw.
All animals were observed for 14 days after dosing for general climical signs, morbidity and mortality.
All animals were weighed on day 1 prior to dosing and on days 8 and 12.
A careful examination was made severla times on the day of dosing and thereafter once daily. - Statistics:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No compound - related mortality was recorded for any animal of step 1 and step 2.
- Clinical signs:
- other: female rat 1-6: No signs of toxicity were observed during the whole observation period.
- Gross pathology:
- At necropsy, some macroscopic changes (female 4 and 5: red spots on the lungs) were observed. These findings are not considered to be test item related.
No specific gross pathological changes were reported.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
Two groups, each of three female Wistar rats, are treated with ditolylether disulfonic acid disodium salt, isomer mixture by oral gavage administration at a dosage of 2000 mg/kg bw (OECD TG 423 and GLP). All animals were observed for 14 days post dosing. No mortality occurred and no clinical signs of intoxication were noted. Body weight gain was within the normal range. At necropsy, no treatment related macroscopic findings were observed in any animal of any step. Thus, the LD50 is > 2000 mg/kg bw.
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