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EC number: 237-537-7 | CAS number: 13827-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance was not irritating to rabbit skin, but irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
In a GLP-compliant OECD guideline 404 study, rabbits were exposed to Nocolok Zn Flux to determine skin irritating properties. 0.5 g of the test substance moistened with 0.2 mL Milli-U water were applied under semi-occlusive conditions to the skin of 3 rabbits for 4 hours. After the removal of the patches animals were observed for 72 hours. No evidence of skin irritation was noted (erythema and edema scores were 0 at all time points (24, 48 and 72 hours) in all animals). Based on the results of the study, Nocolok Zn Flux is considered to be not irritating to skin.
Eye irritation:
In a GLP-compliant OECD guideline 405 study, rabbits were exposed to Nocolok Zn Flux to determine eye irritating properties. 97 mg of Nocolok Zn Flux were instilled into the eye of each of three rabbits. Observations were made 1, 24, 48 and 72 hours and 7, 14 and 21 days after instillation. No staining and no systemic toxicity was observed. Opacity was seen in all animals and also as slight dulling of the normal lustrein in one animal. As a result of the corneal injury, pannus (neovascularisation of the cornea) was apperent in two animals 7 days after instillation. The corneal injury and/or pannus had resolved in one animal within 72 hours and in two animals within 14 days. Irridial irritation (grade 1) was observed in two animals and had resolved within 72 hours and 7 days respectively. Redness, chemosis, and discharge was completely resolved in one animal within 14 days and in the other two within 21 days. Reduced elasticity of the eyelids was seen in one animal 72 hours after instillation and resolved within 14 days. Based on the results the test substance was considered to be irritating to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
GLP-compliant guideline study.
Justification for selection of eye irritation endpoint:
GLP-compliant guideline study.
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the findings in the skin irritation study the test substance does not need to be classified according to the Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. Based on the results of the eye irritation study the test substance needs to be classified as Xi: R36 according to the Directive 67/548/EEC and Cat 2: H319 according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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