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Diss Factsheets
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EC number: 608-782-0 | CAS number: 32765-81-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP. Only a range finding study with few animals was performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Few animals were used.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: range-finding study
- Limit test:
- no
Test material
- Reference substance name:
- (6-Bromohexyl)trimethylammonium bromide
- IUPAC Name:
- (6-Bromohexyl)trimethylammonium bromide
- Test material form:
- other: solid
- Details on test material:
- Name: (6-Bromohexyl)trimethylammonium bromide:
Batch No.: NEU 2592
Appearance: white solid
Storage conditions: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Three male and three female Sprague-Dawley CD strain rats supplied by Charles River (UK) Ltd., were used. At the start of the study the males weighed 150 to 160g, and the females 140 to 146g, and were five to eight weeks of age.
After an acclimatisation period of at least five days the animals were selected at random and given a number unique within the study by indelible ink-marking on the tail and a number written on-a cage card.
The animals were housed in groups of up to three by sex in solid-floor polypropylene cages furnished with woodflakes. With the exception of an overnight fast immediately before dosing and for approximately two hours after dosing, free access to mains drinking water and food (Rat and Mouse Expanded Diet No. 1, Special Diets Services Limited, Witham, Essex, UK) was allowed throughout the study.
The animal room was maintained at a temperature of 19 to 21 °C and relative humidity of 50 to 56%. The rate of air exchange was approximately fifteen changes per hour and the fighting was controlled by a time switch to give twelve hours continuous light and twelve hours darkness.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The animals were fasted overnight before dosing.
Dose volume: 10 mL/kg bw. - Doses:
- 25 - 200 - 2000 mg/kg bw
- No. of animals per sex per dose:
- 1 m + 1 f.
- Control animals:
- no
- Details on study design:
- The test material was freshly prepared, as required, as a solution at the appropriate concentration in distilled water.
- Statistics:
- Using the mortality data obtained, an estimate of the acute oral median lethal dose (LD50) of the test material was made.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One high dosed male died within 30 min p.a.
- Clinical signs:
- other: Clinical signs of toxicity noted in animals treated with 2000 or 200 mg/kg were hunched posture, lethargy and decreased respiratory rate. No clinical signs of toxicity were noted in animals treated with 25 mg/kg.
- Gross pathology:
- Abnormalities noted at necropsy of the male treated with 2000 mg/kg which was found dead 30 minutes after dosing were haemorrhagic lungs, dark liver and dark kidneys.
No abnormalities were noted at necropsy of animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
- Conclusions:
- The acute oral median lethal dose (LDS0) of the test material, (6-Bromohexyl) trimethylammonium bromide, in the Sprague-Dawley CD strain rat was found to be approximately 2000 mg/kg bodyweight.
- Executive summary:
A range finding study was performed. The acute oral median lethal dose (LDS0) of the test material, (6-Bromohexyl) trimethylammonium bromide, in the Sprague-Dawley CD strain rat was found to be approximately 2000 mg/kg bodyweight.
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