Registration Dossier
Registration Dossier
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EC number: 275-069-5 | CAS number: 70969-58-3
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
It is considered that there is sufficient evidence to justify the non-classification of the registered substance for carcinogenicity on the
basis of:1) Negative findings in tests for gene mutation / mutagenicity.
2) Evaluation using Derek Nexus, an accepted (Q)SAR tool designed for the qualitative prediction of the possible toxicity of
chemicals, a procedure in accordance with Annex XI of Regulation 1907/2006. In this, the substance triggered no alerts for
carcinogenicity, chromosome damage, genotoxicity and mutagenicity.
Additional information
The substance has been evaluated over a range of toxicological endpoints and species using Derek Nexus. No alerts for carcinogenicity, chromosome damage, genotoxicity and mutagenicity were triggered and the structure should be regarded as negative for the endpoints.This is supported by available genetic toxicity studies which include a bacterial reverse mutation assay (Ames test), chromosome aberration study in cultured human lymphocytes and a study for the induction of 5‑trifluorothymidine resistant mutants in mouse lymphoma L5178Y cells after in vitro treatment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
