Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-446-6 | CAS number: 106-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August to October 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no deviations from standard test guidelines and no methodological deficiences, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Number of animals: 3 animals were used
Weight: on the day of treatment, the animals had a mean body weight of 2.6±0.3 kg
Acclimatization: at least 5 days before the beginning of the study
Selection of the animals: the days before treatment, the skin of each animal was examined in order to use only animals without any signs of cutaneous irritation
During the acclimatization period and during the main test, the environmental conditions in the animal room were set as follows:
- temperature: 18±3°C
- relative humidity: 50±20%
- light/dark cycle: 12h/12h
The animals were housed individually in polystyrene cages (35 x 55 x 32 cm or 48.2 x 58 x 36.5 cm).
Each cage was equipped with a food container and a water bottle. - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The opposite flank of each animal was used for control
- Amount / concentration applied:
- A dose of 0.5 mL of the test substance was applied to a 6 cm2 dry hydrophilic gauze patch and this was then applied to one flank of the animals.
The test substance and the gauze patch were held in contact with the skin by means of an adhesive hypoallergic aerated semi-occlusive dressing and a restraining bandage. - Duration of treatment / exposure:
- First test with 3 minutes exposure and 2nd tests with 4 hours exposure.
The dressings were removed and no residual test substance was observed.
The animals were then replaced into their individual cages. - Observation period:
- The skin was examined approximately 1, 24, 48 and 72 hours after removal of the dressing.
As there was persistent cutaneous irritation after 72 hours, the observation period was extended to day 15. - Number of animals:
- 3 : 1 for the 3 minutes test and 2 for the 4 hours tests
- Details on study design:
- As the test substance was anticipated to be irritant, a preliminary assay was conducted with an application of the test substance for 3 minutes in animal nb 1 and 4 hours in animal nb 2.
A second application was performed for 4 hours using animal nb 3.
Results from the 4 hour exposure are included in the analysis. - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2.5
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 d
- Score:
- 2.5
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 3 d
- Score:
- 3.5
- Max. score:
- 4
- Irritant / corrosive response data:
- On day 6 necrosis of the skin was noted in one animal.
A crust persisted between days 6 and 15 in the second animal. - Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, allyl bromide was determined as corrosive when administrated by cutaneous route for a period of 4 hours in rabbits
- Executive summary:
The skin irritation potential of allyl bromide was determined according to the following guideline, OECD 404.
Two rabbits were exposed to 0.5 mL of the test material for 4 hours. The area was then observed at intervals over a period of 15 days. The test material was determined as corrosive.
Under CLP regulation the test material should be classified as "Skin Corr. 1B" and assigned the hazard phrase "H314 Causes severe skin burns and eye damage".
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- no data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Eye irritation of allyl bromide is cited in a general handbook on product safety data
- Guideline:
- other: No data
- GLP compliance:
- not specified
- Irritation parameter:
- other: No data
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Based on this handbook allyl bromide cause severe eye burns
- Executive summary:
Based on this handbook allyl bromide cause severe eye burns
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Only one study available
Justification for selection of eye irritation endpoint:
This handbook contains the most important effect of allyl bromide on eyes
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Under experimental conditions, allyl bromide need to be classified as "Skin Corr. 1B" and assigned the hazard phrase "H314 Causes severe skin burns and eye damage" in accordance with the CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.