Registration Dossier
Registration Dossier
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EC number: 266-124-4 | CAS number: 66085-00-5
Endpoint summary
Administrative data
Description of key information
Additional information
Glycerol monoisostearate (CAS 66085-00-5) is readily biodegradable according to OECD criteria (83% in 28 d). The substance is characterised by low water solubility, low vapour pressure and a high log Koc. Hydrolysis is not expected to be a relevant degradation pathway for the substance as indicated by QSAR calculations performed with the HYDROWIN v2.00 program resulting in estimated half-lives in water ranging from 1.51 – 7.71 years (at pH 7) and 55.14 days to 281.6 days (at pH 8) for the main substance components.
The substance is expected to be extensively eliminated in conventional sewage treatment plants. In the case insoluble chemicals enter a standard Sewage Treatment Plant (STP), they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms, according to the Guidance on information requirements and chemical safety assessment, Chapter R.7b (ECHA, 2012). Due to the insolubility and high adsorption potential of the substance (log Koc 2.95 – 13.96 for the main components) the substance is not expected to be present in the water column. Furthermore adsorption of the substance to sewage sludge is possible and thus a further decrease of the substance concentration in the water column is possible (Guidance on information requirements and chemical safety assessment, Chapter R.7b, (ECHA, 2012). In conclusion, the concentration of the substance in conventional STP effluents is expected to be low.
The volatilization potential of the substance is negligible, based on a vapour pressure < 0.0001 Pa at 20°C. Nevertheless, if released into the atmosphere, the substance is expected to be rapidly photodegraded based on the estimated half-lives in air, ranging from 5.30 – 10.17 hours (AOPWIN 1.92 program). Based on the above information, accumulation in air, subsequent transportation through the atmosphere and deposition into other environmental compartments is not anticipated.
Considering the expected high adsorption potential, low volatilization potential and low water solubility, the substance is expected to distribute preferably to soil and sediment if released to the environment. Nevertheless, due to ready biodegradability a rapid and ultimate degradation in all environmental compartments is anticipated. Due to the rapid environmental biodegradation and metabolization via enzymatic hydrolysis a relevant uptake and bioaccumulation in aquatic organisms is not expected. Enzymatic breakdown will initially lead to the free fatty acid and glycerol. From literature it is well known, that these hydrolysis products will be metabolised and excreted in fish effectively (Tocher, 2003). This is supported by BCF values ranging from 0.893 – 36.6 L/kg calculated for the main components (BCFBAF v3.01, Arnot-Gobas, including biotransformation, upper trophic). Please refer to IUCLID Section 5.3.1 for a detailed overview on bioaccumulation of the substance.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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