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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1945
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, short documentation, purity not specified, reliability of detection method unclear

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1945
Report date:
1945

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:

Adipic acid was orally administered to 4 different humans to investigate
the excretion of this compound. Urine was collected and the adipic acid concentration analyzed.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Bernsteinsäure
IUPAC Name:
Bernsteinsäure
Test material form:
not specified
Details on test material:
IUCLID4 Test substance: purity not specified
Radiolabelling:
not specified

Test animals

Species:
human
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
/

Administration / exposure

Route of administration:
other: no data
Vehicle:
not specified
Details on exposure:
/
Duration and frequency of treatment / exposure:
/
Doses / concentrations
Remarks:
Doses / Concentrations:
/
No. of animals per sex per dose / concentration:
/
Control animals:
not specified
Positive control reference chemical:
/
Details on study design:
/
Details on dosing and sampling:
/
Statistics:
/

Results and discussion

Preliminary studies:
/

Toxicokinetic / pharmacokinetic studies

Details on absorption:
/
Details on distribution in tissues:
/
Details on excretion:
/
Toxicokinetic parameters
Test no.:
#1
Toxicokinetic parameters:
other: One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administere

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
/

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:
/

Any other information on results incl. tables

One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administered dose was found in the urine. Three further persons received 23.4, 19.0, and 23.4 g adipic acid over 6, 5, and 9 days, respectively. 53% of the administered dose was found in the urine. No symptoms were reported during and after exposure

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no data
/