Registration Dossier
Registration Dossier
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EC number: 250-157-6 | CAS number: 30374-01-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: National Guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The procedure described in Section 191.11 of the Federal Hazardous Substances Labeling Act was followed.
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isooctyl 3-mercaptopropionate
- EC Number:
- 250-157-6
- EC Name:
- Isooctyl 3-mercaptopropionate
- Cas Number:
- 30374-01-7
- Molecular formula:
- C11H22O2S
- IUPAC Name:
- 2-methylheptyl 3-sulfanylpropanoate
- Details on test material:
- - Name of test material (as cited in study report): Iso-octyl 3-mercaptopropionate
- Analytical purity: no data
- Other: sample number bl 1409
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- Removal of the test material from the skin after 24 hours .
- Observation period:
- The treated areas were scored according to the Federal Hazardous Substances Labeling Act, 24 and 72 hours after initiation of the test.
- Number of animals:
- 6 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- 24 hours after application of the test material, the gauze was removed and the skin gently cleaned
SCORING SYSTEM: The treated areas were scored according to the Federal Hazardous Substances Labeling Act.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: no reading at 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Remarks on result:
- other: no reading at 48 h
- Other effects:
- A primary irritation index of 0 was calculated for the test material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the test material is not considered to be a dermal irritant.
GHS: not classifiable
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