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EC number: 939-719-8 | CAS number: 5502-75-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 07-2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ECOSAR
2. MODEL (incl. version number)
v2.2
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CC(C)C2CCC(CO)CC2
See other input values in the QPRF attached.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See detailed information in QPRF/QMRF attached.
5. APPLICABILITY DOMAIN
See detailed information in QPRF/QMRF attached.
6. ADEQUACY OF THE RESULT
See detailed information in QPRF/QMRF attached. - Qualifier:
- no guideline required
- Principles of method if other than guideline:
- see filed "Justification for type of information"
- Analytical monitoring:
- yes
- Remarks:
- Data included in ECOSAR are based on measured test concentrations maintained at greater than 80% of nominal concentrations.
- Test organisms (species):
- Daphnia sp.
- Test type:
- other: Semi-static or flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Hardness:
- < 150 mg CaCO3/L
- pH:
- 6-8
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.35 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Validity criteria fulfilled:
- yes
- Remarks:
- Applicability domain of the QSAR model respected.
- Conclusions:
- The daphnia 21-d NOEC is predicted to be 0.350 mg/L.
- Executive summary:
The daphnia 21-d NOEC was predicted using the software ECOSAR v2.2. The prediction is based on the equation for neutral organics. The results indicate that the NOEC is 0.350 mg/L. The calculation is reliable, validated and the substance properties fall within the applicability domain of the QSAR.
Reference
Description of key information
QSAR ECOSAR, 2022, K
21-d NOECdaphnia = 0.350 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.35 mg/L
Additional information
One QSAR is avaible to assess the chronic toxicty of the registered substance to aquatic invertebrate.
The daphnia 21-d NOEC was predicted using the software ECOSAR v2.2. The prediction is based on the equation for neutral organics. The results indicate that the NOEC is 0.350 mg/L. The calculation is reliable, validated and the substance properties fall within the applicability domain of the QSAR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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