O,O-dimethyl hydrogen dithiophosphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

may-june 1973

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Mice of CFLP strain in the weight range 16 to 23 g were straved overnight before treatment with MP-1. Mp-1 was prepared as a 10% v/v emulsion in Tween 80 (10% aqueous dilution) and administrered at a maximum dosage volume of 16 ml/kg bodyweight. Mice treated with Tween 80 in water served as controls.

GLP compliance:

no

Test type:

other:

Test material

Test material information

Constituent 1

Reference substance name:

0,0-dimethyl-dithiophosphoric acid

IUPAC Name:

0,0-dimethyl-dithiophosphoric acid

Test animals

Species:

mouse

Strain:

other: CFLP

Sex:

male/female

Administration / exposure

Route of administration:

oral: drinking water

Vehicle:

other:

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10% v/v in Tween-80
- Amount of vehicle : maximum dose of 16 ml/kg

Doses:

0.0 ml/kg, 0.25 ml/kg, 0.4 ml/kg, 0.64 ml/kg, 1.0 ml/kg, 1.6 ml/kg

No. of animals per sex per dose:

5

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

996 mg/kg bw

Based on:

test mat.

95% CL:

>= 905 - <= 1 099

Mortality:

Death occured between 2 and 43 hours after treatment

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 for mice were found to be 996 mg/kg bw