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Diss Factsheets
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EC number: 309-629-8 | CAS number: 100545-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Aquatic bioaccumulation testing was not deemed scientifically necessary as all main constituents (components “1” to “6”, representing up to 100% of the test substance, for more details cf. log Kow data and Boundary Composition section) have log Kow values higher than 10 (11.31 to 25.96) and the test substance is highly insoluble (<0.1 µg/L). According to the Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.11 (PBT/vPvB assessment), log BCF values decrease as log Kow increases for substances with very high log Kow values (> 6) and it is unlikely that a substance bioaccumulates significantly if log Kow > 10. As a result of these properties, bioavailability for aquatic organisms is expected to be low. Furthermore, the molecular weights of these 6 components are 625, 609, 907, 1190, 891 and 593 g/mol, respectively. According to Lipinksi et al. (1997), a substance with such properties (log Kow > 5 and MW > 500 g/mol) and more than 5 H-bond donors and 10H-bond acceptors is unlikely to cross a biological membrane in amounts sufficient to exert toxic response. Moreover, Dimitrov et al. (2005) showed that substances with log Kow values higher than 10 had BCF values significantly lower (<1000 L/kg) than the threshold of 2000 L/kg ww. Furthermore, according to Rekker and Mannhold (1992), a combination of a log Kow values higher than 8 and molecular weights higher than 700 g/mol can be used to conclude that the test substance is unlikely to bioaccumulate.
These six main components can represent up to 100% of this UVCB; nevertheless, there may be minor components and residuals representing up to 3.6% (components 7 to 10, cf. log Kow data and Boundary Composition). None of these potential constituents fulfill PBT or vPvB criteria (cf. QSAR BCFBAF data and PBT/vPvB assessment). Therefore, it is not considered scientifically necessary to further investigate the bioaccumulation potential of these constituents.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.