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EC number: 411-280-2 | CAS number: 74091-64-8 MR-8A; MR-N2; NBDI
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 9, 1990 - August 12, 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted equivalent to OECD 401 and GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Guideline for Toxicity Study of Drugs (1989)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-bis-isocyanatomethyl-bicyclo[2.2.1]heptane
- EC Number:
- 411-280-2
- EC Name:
- 2,5-bis-isocyanatomethyl-bicyclo[2.2.1]heptane
- Cas Number:
- 74091-64-8
- Molecular formula:
- C11H14N2O2
- IUPAC Name:
- (1R,2R,4R,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1R,2S,4R,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2R,4S,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2S,4S,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; bis((1r,2R,4s,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane); bis((1s,2R,4r,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane)
- Details on test material:
- - Name of test material (as cited in study report): NBDI
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan
- Age at study initiation: 5 weeks
- Weight at study initiation: 120-130 g for males and 95-110 g for females
- Housing: polycarbonate cage with hard wood chip bedding
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 25 C
- Humidity (%): 40 to 70%
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE: Olive oil
MAXIMUM DOSE VOLUME APPLIED: 1 mL/100 g bw - Doses:
- 700 mg/kg
1000 mg/kg
1400 mg/kg
2000 mg/kg
(both sexes) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical signs of all rats were inspected and recorded 0.5, 1, 3 and 6 hours after administration and at least once a day thereafter for 14 days.
The bodyweight of all rats was measured shortly before administration and on the 3rd, 7th and 14th day after administration (defining the day of administration as the 0th day)
- Necropsy of survivors performed: yes (and the dead animals were autopsied at discovery)
- Other examinations performed: no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 201 mg/kg bw
- 95% CL:
- 826 - 1 744
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 842 mg/kg bw
- 95% CL:
- 1 387 - 2 446
- Mortality:
- Male: 700 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1400 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 700 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1400 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4 - Clinical signs:
- other: Rats of both sexes at all dose levels had soiled hair around the anus, soft feces and diarrhea between 30 minutes and the second day after administration. One male rat of the 1400 mg/kg dose group had reduced spontaneous movement on the next day after adm
- Gross pathology:
- -Autopsy at the end of the observation period revealed thickening of the stomach internal wall in all rats
-Greyish changes at the stomach wall and yellow contents in the small intestines (females: 1400 and 2000 mg/kg; males: 2000 mg/kg bw only)
-Testes atrophy at the highest dose in males
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 oral was 1842 mg/kg for male rats (95% confidence limits: 1387 to 2446 mg/kg) and 1201 mg/kg for female rats (95% confidence limits: 826 to 1744 mg/kg).
- Executive summary:
The substance was administered orally to SD strain rats (SPF) of both sexes and its acute toxicity was determined. The dosage levels were 700, 1000, 1400 and 2000 mg/kg for rats of both sexes. Each dose group consisted of 5 rats.
The LD50 oral was 1842 mg/kg for male rats (95% confidence limits: 1387 to 2446 mg/kg) and 1201 mg/kg for female rats (95% confidence limits: 826 to 1744 mg/kg).
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