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Reaction mass of Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)Vinyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)]-, sodium and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[2-(sulfooxy)Ethanol]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt
EC number: 941-883-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From July 5 to 8,1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Complete read across justification is attached in section 13. Source study has reliability 1.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- RA Substance 01
- IUPAC Name:
- RA Substance 01
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG
- Weight at study initiation: 3 - 4 kg
- Housing: in individual cages in air-conditioned rooms
- Diet : Breeding diet Altromin 2013 - Rabbit (Altromin GmbH, Lage / Lippe), ad libitum
- Water : deionized water, chlorinated water from automatic watering tables, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 2 °C
- Humidity: 55 ± 10 %
- Photoperiod: 12 hrs cycle dark/light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: pasted with 0.25 mL PEG400
- Controls:
- not required
- Amount / concentration applied:
- 500 mg pasted with 0.25 mL PEG400 applied to shaved skin of 2.5 cm × 2.5 cm.
- Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 30 min, 24 h , 48 h , 72 h after removal of the patches.
- Number of animals:
- 3 rabbits.
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm × 2.5 cm
- Type of wrap if used: semi-occlusive
REMOVAL OF TEST SUBSTANCE
- Washing: after the 4 hours exposure period
SCORING SYSTEM: according to Draize
Erythema and eschar formation
0 No erythema
1 Very slight, barely perceptible erythema
2 Well developed erythema
3 Moderate to severe erythema
4 Severe erythema (dark red) to slight eschar formation (injury in the depth of the skin)
Oedema formation
0 No oedema
1 Very light, hardly perceptible oedema
2 Light oedema, boundaries are well marked by a distinct elevation.
3 Medium oedema, lift off about 1 mm
4 Heavy oedema, lifting more than 1 mm and exceeding the limits of the application site
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
Any other information on results incl. tables
time post-application | animal | erythema | oedema |
1 h | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 | |
24 h | 1 | 1 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 | |
48 h | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 | |
72 h | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: non irritant according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- In the experimental conditions described by OECD guideline 404 for the examination of acute dermal irritation / corrosion potential, test substance resulted as not irritant to the skin.
- Executive summary:
Method
Examination of acute dermal irritation/corrosion in 3 rabbits according to OECD guideline 404, by semiocclusive application of test substance on shaved skin for 4 hours.
Results
No signs of irritation were noted except for one animal showing very slight erythema after 24 hours. However, it reversed within 48 hours. Consequently, test substance is considered as non irritant to the skin.
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