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Diss Factsheets
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EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Adequacy of study:
- supporting study
- Study period:
- 1971-12-02 to 1972-01-05
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-GLP/non-guideline study (this study was conducted in the United States prior to issue of the OPPTS harmonised Test Guidelines). The exposure period was 24 hours (rather than 4 hours as specified in OECD Guideline 404), the result is therefore not considered to be valid for the purposes of classification. In addition, no consideration was given to a possible effect on the skin from the administration of the test substance which was warmed to 46oC.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- DMOP was applied to the clipped intact skin of New Zealand White male and female rabbits under a one inch by one inch square patch which was held in place by an occlusive dressing for an exposure period of 24 hours. Observations were made over a period of seven days for irritation and scored according to the method of Draize, Woodard and Calvery.
- GLP compliance:
- no
- Remarks:
- The study was performed in 1972.
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Reference substance name:
- M-5925
- IUPAC Name:
- M-5925
- Test material form:
- other: waxy solid
- Details on test material:
- Test Item Identification: M-5925. Test substance adminstered undiluted, warmed to 115°F (46°C), to liquefy.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 3 animals (2 ♂ and 1 ♀)
- Details on study design:
- 0.5 ml of undiluted Dimethyl octadecylphosphonate (DMOP) was applied to the clipped intact skin of New Zealand White male and female rabbits.
TEST SITE
- Area of exposure: 1inch × 1 inch gauze patches
- % coverage: not reported
- Type of wrap if used: the patches were held in place with adhesive tape. The trunk of each animal was wrapped with plastic strips, to retard evaporation and avoid contamination for the 24 hour exposure period
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not applicable
SCORING SYSTEM: Observations were made over a period of seven days for irritation and scored according to the method of Draize, Woodard and Calvery.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 168 hours
- Remarks on result:
- other: The exposure period was 24 hours (rather than 4 hours as specified in OECD Guideline 404), the result is therefore not considered to be valid for the purposes of classification.
Any other information on results incl. tables
Animal Number/Sex |
1 Hour |
24 hours |
48 hours |
72 hours |
120 hours |
168 hours |
1- Male |
0 |
7 |
8 |
8 |
8 |
8 |
2 – Female |
0 |
6 |
8 |
8 |
8 |
8 |
3 - Male |
0 |
7 |
8 |
8 |
8 |
8 |
Average |
0 |
6.6 |
8 |
8 |
8 |
8 |
Applicant's summary and conclusion
- Interpretation of results:
- other: The result is not considered to be valid for the purposes of classification since the exposure period was 24 hours rather than 4 hours as specified in OECD Guideline 404.
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- It was concluded by the author that DMOP was a "corrosive irritant", however the test (conducted in 1972) was not performed to GLP or test guidelines and the exposure period was 24 hours rather than 4 hours as specified in OECD Test Guideline 404. The result is therefore not considered to be valid for the purposes of classification.
- Executive summary:
0.5 ml of undiluted Dimethyl octadecylphosphonate (DMOP) was applied to the clipped intact skin of New Zealand white male and female rabbits under a one inch by one inch square patch, two single layers thick. The patches were held in place with adhesive tape. The trunk of each animal was wrapped with plastic strips, to retard evaporation and avoid contamination for the 24 hour exposure period. Observations were made over a period of seven days for irritation and scored according to the method of Draize, Woodard and Calvery.
It was concluded by the author that DMOP was a "corrosive irritant", however the test (conducted in 1972) was not performed to GLP or test guidlines and the exposure period was 24 hours rather than 4 hours as specified in OECD Test Guideline 404. The result is therefore not considered to be valid for the purposes of classification.
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