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Diss Factsheets
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EC number: 214-770-2 | CAS number: 1193-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- minor deviations e.g. dose level
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4,6-dichloropyrimidine
- EC Number:
- 214-770-2
- EC Name:
- 4,6-dichloropyrimidine
- Cas Number:
- 1193-21-1
- Molecular formula:
- C4H2Cl2N2
- IUPAC Name:
- 4,6-dichloropyrimidine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 2000 mg/kg/b.w.
200 mg/kg/b.w. - No. of animals per sex per dose:
- 3 females 2000 mg/kg/b.w.
3 females 200 mg/kg/b.w.
3 males 200 mg/kg/b.w. - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The LD50 value for male and female rats is greater than 200 mg/kg and was not exactly determined.
Any other information on results incl. tables
Animals employed as well as mortality
dose (mg/kg b.w) sex number of animals* time of deaths mortality %
200 m 0/3 0
200 f 0/3 0
2000 f 2/3 3 hours 67
* number of animals dying/number of animals employed
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value for male and female rats is greater than 200 mg/kg and was not exactly determined.
Based on the investigations, the test substance has to be regarded as harmful if swallowed. - Executive summary:
Toxicological investigations in male and female rats were conducted after single oral administration of 4,6 -dichloropyrimidine. The LD50 was greater than 200 mg for the male and female rats.
After administration of 2000 mg/kg body weight the following clinical signs were observed in female rats: dazed condition and apathy. Two of three animals died.
After a single doese of 200 mg/kg no signs were observed in male rats, females showed piloerection up to 8 hours after application.
Body weight development was not significantly affected in both sexes after 200 mg/kg.
At necroscopy of the two intercurrent deaths females (2000 mg/kg) showed the following gross pathological findings: strong reddening of the muscosa in stomach and small intestine, liver mottled.
None of the animals sacrified at the end of study showed any noticeable gross pathological findings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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