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Diss Factsheets
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EC number: 202-498-7 | CAS number: 96-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid study, comparable to guideline, but not according to current standards or GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- publication
- Title:
- 1,3-Dimethylurea (CAS: 96-31-1), SIDS Initial assessment report for SIAM 17
- Author:
- OECD SIDS
- Year:
- 2 009
- Bibliographic source:
- Unep publications
- Report date:
- 2003
Materials and methods
- Principles of method if other than guideline:
- BASF test: In principle, the methods described in OECD Guideline 401 were used.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-dimethylurea
- EC Number:
- 202-498-7
- EC Name:
- 1,3-dimethylurea
- Cas Number:
- 96-31-1
- Molecular formula:
- C3H8N2O
- IUPAC Name:
- 1,3-dimethylurea
- Details on test material:
- - Name of test material (as cited in study report): 1,3-Dimethylurea, N,N'-Dimethylurea
- Physical state: cristalline
- Analytical purity: technical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeder
- Age at study initiation: Young adult
- Weight at study initiation: Average weight at beginning of the test: 96 - 174 g
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: The doses were applied as 1 % or 10% preparations of the test substance in aqua dest.
MAXIMUM DOSE VOLUME APPLIED: no data
DOSAGE PREPARATION (if unusual):
- The concentrations of these preparations were usually adjusted to achieve comparable volumes (e.g. 10 ml) per kg body weight. - Doses:
- 20; 79; 316; 1260 mg/kg (1 animal per dose); 3160; 5010; 6310; 7940; 10000 mg/kg (5 animals per dose)
- No. of animals per sex per dose:
- 5 rats per dose group, except for the four lowest dose levels (1 rat/dose).
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Body weight was determined before the beginning of the study for dose calculation.
Observation of clinical signs was several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: no, only of the died animal. - Statistics:
- On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Results are given as dead animals/total number of animals at this dose at 24 h, 48 h and 7 days after dosing:
20 mg/kg bw: 0/1, 0/1, 0/1
79 mg/kg bw: 0/1, 0/1, 0/1
316 mg/kg bw: 0/1, 0/1, 0/1
1260 mg/kg bw: 0/1, 0/1, 0/1
3160 mg/kg bw: 0/5, 0/5, 0/5
5010 mg/kg bw: 0/5, 0/5, 4/5
6310 mg/kg bw: 0/5, 4/5, 5/5
7940 mg/kg bw: 1/5, 5/5, 5/5
10000 mg/kg bw: 5/5, 5/5, 5/5 - Clinical signs:
- other: unspecific; apathy and narcotic like state at doses near to or exceeding the LD50. None of the animals had blood in the urine. SYMPTOMS PER DOSE GROUP: 20-3160 mg/kg bw: no symptoms 5010 mg/kg bw: piloerection, vocalisation during urination 6310-7940 m
- Gross pathology:
- In 2 animals stomach filled with liquid and dilated, all other animals without findings in the inner organs . Necropsy was performed by a pathologist.
- Other findings:
- No other fndings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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