Registration Dossier
Registration Dossier
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EC number: 273-050-6 | CAS number: 68936-98-1 The complex combination of hydrocarbons produced by the distillation of products from cumene manufacturing process. It consists primarily of diisopropylbenzene with various small amounts of C4 substituted benzenes and heavier non-aromatic hydrocarbons.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Validated test method for assessment of the eye irritating potential
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- Hen's Egg Test – Chorioallantoic Membrane (HET-. CAM) test system; validated test method for assessment of the eye irritating potential
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- (Laus GmbH)
Test material
- Reference substance name:
- Cumene bottoms (benzene, (1-methylethyl)-, distn. residues)
- IUPAC Name:
- Cumene bottoms (benzene, (1-methylethyl)-, distn. residues)
- Details on test material:
- Batch number 341309
Yeliowish Liquid.
UVCB substance (Benzene, (1-methylethyl)-, distn. Residues)
CAS No 68936-98-1
This substance is an UVCB. Under this definition, no components can be considered as impurities (purity 100%)
Constituent 1
Test animals / tissue source
- Species:
- other: in vitro model
- Strain:
- other: not applicable
- Details on test animals or tissues and environmental conditions:
- Leghorn chicken eggs (9 days old) incubated at 38.5 ± 0.2 °C and 59% ± 2% humidity for further 9 days before use
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: negative control: 0.9% NaCl in deionised water
- Amount / concentration applied:
- 0.3 mL
- Duration of treatment / exposure:
- 300 sec
- Observation period (in vivo):
- 300 sec
- Number of animals or in vitro replicates:
- 6 eggs for test item and 3 eggs for each control
- Details on study design:
- irritating potential of the test item by detection of damages in blood vessels under the chorioallantoic membrane of incubated chicken eggs
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 300 sec
- Score:
- 6.46
- Max. score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- other: moderately irritant
- Irritant / corrosive response data:
- valid positive (induced a severe irritation on the blood vessels) and negative controls (no irritating effect on the blood vessels under the membrane).
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information
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