Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 279-013-0 | CAS number: 78948-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- but the studies follow quality assurance standards
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at six to seven spaced points troughout the study duration. Samples stored at 7 °C before analysis.
- Buffers:
- Buffer solution pH 4.4:
No buffer necessary, only H2O was used
Buffer solution pH 6.9:
0.1 M phosphate buffer: 680 mg KH2PO4 (Merck, Darmstadt) and 2.98 mL 1 M NaOH (Merck, Darmstadt) filled up to 50mL with H2O
Buffer solution pH 8.8:
0.2 M borate buffer: 618 mg boric acid (Merck, Darmstadt) and 3.98 mL 1 M NaOH (Merck, Darmstadt) were filled up to 50 mL with H2O - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 5 mm NMR tubes
TEST MEDIUM
- Test concentrations: 2% MMPP
- Preparation of test medium: 2% MMPP in H2O or buffer/ D2O (90/10 %v/v)
- Replicates: Single replicate for each measuring date - Duration:
- 21.07 h
- pH:
- 4.4
- Temp.:
- 27 °C
- Initial conc. measured:
- 2 other: %
- Duration:
- 22.81 h
- pH:
- 6.9
- Temp.:
- 27 °C
- Initial conc. measured:
- 2 other: %
- Duration:
- 12.3 h
- pH:
- 8.8
- Temp.:
- 27 °C
- Initial conc. measured:
- 2 other: %
- Statistical methods:
- r2 > 0.9 in all log concentration/ time relationships
- Preliminary study:
- none
- Transformation products:
- yes
- No.:
- #1
- pH:
- 4.4
- Temp.:
- 27 °C
- DT50:
- 6.04 h
- pH:
- 6.9
- Temp.:
- 27 °C
- Remarks on result:
- not determinable
- Remarks:
- Dt50 can not be calculated due to possible interference of the test compound with the phosphate buffer used
- pH:
- 8.8
- Temp.:
- 27 °C
- DT50:
- 3.21 h
- Validity criteria fulfilled:
- yes
- Conclusions:
- The studies clearly prove rapid hydrolysis of MMPP. Products of hydrolysis are Phthalic acid and H2O2. Complete hydrolysis is to be expected under environmental conditions and in human body fluids.
- Executive summary:
The hydrolysis of MMPP was studied using 13C-NMR technique. The test substance was mixed with H2O/D2O to obtain a 2% solution at 27°C; pH values were adjusted to 4.4, 6.9 and 8.8. The degree of hydrolysis was measured by detection of MMPP and Phthalic acid via the 13C-NMR-spectra.
Samples were analysed at the start of the test and at minimum 5 spaced time points during the test. The concentrations were analysed via NMR spectrometer.
The substance hydrolyses at pH 4.4, 6.9 and 8.8.
Degradation products were Phthalic acid and H2O2 (not detectable via 13C-NMR).
Reference
Degradation products were Phthalic acid and H2O2 (not detectable via 13C-NMR).
Description of key information
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.