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EC number: 277-242-0 | CAS number: 73037-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Ditolylether disulfonic acid disodium salt, isomer mixture causes no irrtating effects neither on the skin of rabbits nor in the eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: female: approx. 23-24 weeks
- Weight at study initiation: > 2 kg
- Housing: individually
- Diet ad libitum
- Water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: test substance was only moistened
- Controls:
- other: The opposite site of the treatment area served as control.
- Amount / concentration applied:
- 0.5 g to each test side, moistened with water to ensure good contact to the skin.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours post treatment
- Number of animals:
- 3
- Details on study design:
- The test item ws applied first to a gauze patch.
To ensure good skin contact it was moistened with tap water.
The patch was then applied to the skin on a small area (approx 6cm² of the left side of the dorsal area ; the right side served as control).
The patch was fixed with a semi-occlusive dressing for a 4-hour period.
At the end of the exposure operiod the residual test item was removed with tap water.
All animals were observed for 72 hours after the patch removal.
Scoring for oedema and erythema was made according to Draize. - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: no signs of erythema were reported
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: no signs of oedema were reported
- Irritant / corrosive response data:
- No irritant or corrosive effects were observed on the intact skin of thee female rabbits after a contact time of 4 hours.
- Other effects:
- Neither mortality nor significant clinical signs of toxicity were observed.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Three New Zealand white rabbits received dermal application of 0.5 g moistened ditolylether disulfonic acid disodium salt, isomer mixture to the shaved dorsal skin (left side) for 4 hours. The right side of the dosal skin served as control (OECD TG 404). The test substance was held in place by a semi-occlusive dressing. After termination of the exposure the residue test substance was removed with tap water. The animals were observed for 72 hours post treatment. Under the conditions of the study ditolylether disulfonic acid disodium salt, isomer mixture caused no irritating or corrosive skin effect. No clinical signs of systemic intoxication are observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: animal 1: 19 weeks, animal 2: 34 weeks, animal 3: 30-31 weeks
- Weight at study initiation: > 2 kg
- Diet ad libitum
- Water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye of each animal served as control.
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- once
- Observation period (in vivo):
- up to 6 days
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- The test item was applied at a single dose (100 mg) into the conjunctival sac of one eye of each test animal after pulling the lower lid away from eyeball. The lids were then gently held together for about 1 sec in order to prevent loss of the material. The untreated contralateral eye served as control. The treated eye was not rinsed. The eyes were examined for signs of irritation throughout the observation period. The eye irritation was scored according to Draize.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- >= 0.67 - <= 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- other: animal 1: score 1 of max 3 for 72 h; animal 2: score 1 for 48 h: amimal 3: score 1 for 72 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The only effects observed: Some blood vessels were hyperaemic (conjunctival injections, score 1 of max 3), which was fully reversible within 6 days.
- Other effects:
- no effects reported
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- The animals showed slightly irritation effects which were fully reversible within 6 days and which do no lead to classification.
- Executive summary:
Ditolylether disulfonic acid disodium salt, isomer mixture was tested for eye irritating property using 3 female New Zealand White rabbits. The test item was applied at a single dose (100 mg, undissolved) into the conjunctival sac of one eye of each test animal after pulling the lower lid away from eyeball. The lids were then gently held together for about 1 sec in order to prevent loss of the material. The untreated contralateral eye served as control. The treated eye was not rinsed. The eyes were examined for signs of irritation throughout the observation period. The eye irritation was scored according to Draize. The animals showed slightly irritation effects (conjunctival injections) most probabely due to mechanical irritation by the undissolbed substance. These effects were fully reversible within 6 days and do no lead to classification.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
Threewhite rabbits received dermal application of 0.5 g moistened ditolylether disulfonic acid disodium salt, isomer mixture to the shaved dorsal skin (left side) for 4 hours, the right side of the dosal skin served as control (OECD TG 404). The test substance was held in place by a semi-occlusive dressing. After termination of the exposure the residue test substance was removed weith tap water. The animals were observed for 72 hours post treatment. Under the conditions of the study ditolylether disulfonic acid disodium salt, isomer mixture caused no irritating or corrosive skin effect.
Eye irritation
Ditolylether disulfonic acid disodium salt, isomer mixture was tested for eye irritating property usindg 3 female New Zealand White rabbits(OECD TG 405). The test item was applied at a single dose (100 mg) into the conjunctival sac of one eye of each test animal after pulling the lower lid away from eyeball. The lids were then gently held together for about 1 sec in order to prevent loss of the material. The untreated contralateral eye served as control. The treated eye was not rinsed. The eyes were examined for signs of irritation throughout the observation period. The eye irritation was scored according to Draize. The animals showed slightly irritation effects (conjunctival injections) which were fully reversible within 6 days and which do no lead to classification.
Overall conclusion
The two studies which are taken into account, are GLP compliant and are of high quality (Klimisch score = 1). Therefore, there is no reason to believe that the above described results would not be applicable to humans.
Justification for selection of skin irritation / corrosion endpoint:
only one in vivo study available
Justification for selection of eye irritation endpoint:
only one in vivo study available
Justification for classification or non-classification
Based on the available data no classification and labelling is required.
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