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Diss Factsheets
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EC number: 269-824-8 | CAS number: 68334-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Early 1980's
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results published in a scientific review. and peer reviewed in the European RAR.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The test concentrations of the surfactants during the chronic toxicity studies were confirmed using a recently developed technique. The extracted quaternary ammonium chloride compounds are separated and quantified using HPLC with a conductivity detector.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Early instar daphnids (< 24 h old)
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Hardness:
- 345-363 (White river)
- pH:
- 8.4-8.6 (White river)
- Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.38 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- in river water
- Basis for effect:
- other: reproduction and mean length
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.72 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- in river water
- Basis for effect:
- reproduction
- Remarks on result:
- other: 1.31-2.49
- Conclusions:
- 21-Day NOEC = 0.38 mg/L (reproduction)
- Executive summary:
The no observed effect concentration (NOEC) for daphnids exposed to 14C-labeled DSDMAC in river water was 0.38 mg/L. Length, total young and mean brood size of adults exposed to mean concentrations of >= 0.76 mg/L DSDMAC were significantly less (p ≤ 0.05) than the same parameters for adults in the controls and in the remaining test waters. For example, total young produced at the 0.76 mg/L concentration was approximately 38% less than that for adults exposed to 0.38 mg/L. Mean brood sizes reflected these differences in young production, generally declining at concentrations > 0.38 mg/L. Reproductive performance was more sensitive than mortality: the 21-d LC50 was 1.72 (95%CI = 1.31-2.49) mg/L. Based on the toxicity data for daphnids in river water, the acute to chronic ratio or application factor is 0.12 (NOEC/LC50=0.38/3.1).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.38 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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