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EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion, in vivo (OECD 404): not irritating
Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)
Eye irritation / serious eye damage, in vivo (OECD 405): not irritating
Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982a
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- Slight erythema and edema formation were observed after 4 h exposure of the source substance to shaved rabbit skin under occlusive conditions. Effects were fully reversible within 7 days.
- Executive summary:
The skin irritation / corrosion potential of the target substance is predicted based on an adequate and reliable in vivo study of a structural analogue source substance. Exposure for 4 h of the test substance to the shaved skin of rabbits under occlusive conditions resulted in slight erythema and edema formation. Effects were fully reversible within 7 days. Therefore, no hazard regarding skin irritation / corrosion is identified for the target substance. As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the skin irritation / corrosion potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982b
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982b
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982b
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Meisel, 1982b
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- Application of the unchanged source substance to the eyes of rabbits resulted in no effects regarding corneal opacity, iridial, conjunctival and chemosis responses. The mean scores of all effects at 24/48/72 h over all 3 animals was 0.
- Executive summary:
The eye irritation potential of the target substance is predicted based on an adequate and reliable in vivo study of a structural analogue source substance. Application of the unchanged test substance to the eyes of rabbits resulted in no occular effects at all. The mean scores of all effects at 24/48/72 h for each animal was 0. Therefore, for the target substance no hazard regarding eye irritation / severe eye damage is identified. As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the eye irritation potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data on skin irritation / corrosion and eye irritation / serious eye damage with 2,6-diisopropylnaphthalene (CAS 24157-81-1) are available. These endpoints, therefore, are assessed by means of read-across from the analogue source substance bis(isopropyl)naphthalene (CAS 38640-62-9).
Skin irritation / corrosion
The potential to induce skin irritation or corrosion of bis(isopropyl)naphthalene (CAS No. 38640-62-9) was tested in an in vivo study according to OECD guideline 404 under GLP conditions (Meisel, 1982a). The application of 0.5 mL of the unchanged test substance to the shaved skin of the dorsal area of the trunk (size approx. 2.5 x 2.5 cm) of 3 female New Zealand White rabbits for 4 h under an occlusive and impermeable adhesive dressing resulted in slight skin reactions. Skin reactions were scored after 1, 24, 48, 72 h, 7 days and 14 days after removal of the test patch. The remaining test substance was removed by wiping with single-use paper towels. Slight erythema formation (24/48/72 h mean score 1 in all 3 animals) and slight edema (24/48/72 h mean score 0.33 for 2 and 0.66 for the remaining animal) were observed. In one animal, a slight lesion (48 h) and scab formation (72 h) was observed at the application site in addition. All animals showed desquamation on Day 7. After 14 days, all irritation effects had subsided, and no more findings were noted. The test substance was assessed to have no irritation / corrosion potential.
Eye irritation / serious eye damage
In an in vivo eye irritation study according to OECD guideline 405 following GLP provision with bis(isopropyl)naphthalene (CAS No. 38640-62-9) (Meisel, 1982b), 0.1 mL of the unchanged test substance was instilled in the conjunctival sac of one eye of 3 New Zealand White rabbits. The untreated eye of each animal served as control. Occular reactions were scored according to the Draize scheme. Only a slightly irritating effect (conjunctivae redness score 1) was observed in all test animals 1 h after test substance administration. At the 24 h reading, this finding had subsided and was not seen any more. Scores for all eye irritation parameters in all animals were 0, starting from 24 h onwards. The observation was terminated at the 72 h reading time point due to the lack of any visible effects. The test substance was evaluated not to induce eye irritation.
Conclusion
Based on the results of the in vivo studies for skin irritation / corrosion and eye irritation / serious eye damage with the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) no potential to induce skin or eye irritation is expected for the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1).
Justification for classification or non-classification
The available data on skin irritation / corrosion and eye irritation / serious eye damage for the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP). Data are, therefore, conclusive but not sufficient for classification. Based on an analogue read-across approach, the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1) also does not warrant classification for these human health endpoints.
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