Registration Dossier
Registration Dossier
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EC number: 210-734-5 | CAS number: 622-40-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP and non guideline study, but similar to EU and OECD guideline. The study is sufficient for risk assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Hydroxyethylmorpholine
- Author:
- Papciak, R.J. and Mallory, V.T.
- Year:
- 1 990
- Bibliographic source:
- Acute Tox. Data 1, 16-17 (1990)
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-morpholinoethanol
- EC Number:
- 210-734-5
- EC Name:
- 2-morpholinoethanol
- Cas Number:
- 622-40-2
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 2-(morpholin-4-yl)ethan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 to 3 kg
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: backs of the animals
- % coverage: abot 10% of the total body area
- Type of wrap if used: non-occluding dressing - Duration of exposure:
- single exposure for 24 h
- Doses:
- 6300, 8000, 10000 and 160000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- no statistics
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality pattern : 1/10 @ 6300 mg/kg bw; 0/10 @ 8000, 10000 and 16000 mg/kg bw
- Clinical signs:
- other: no data
- Gross pathology:
- Necropsy findings (study death) determined that death was not compound related.
Terminal necropsy: No visible lesions were observed. - Other findings:
- None
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
