Registration Dossier
Registration Dossier
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EC number: 437-970-3 | CAS number: 371921-62-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Red 0106-PP1
- IUPAC Name:
- Red 0106-PP1
Constituent 1
Study design
- Analytical method:
- other: HPLC with UV/VIS-detection
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.7
- Temp.:
- 20 °C
- Remarks on result:
- other: pH of the solutions analyzed not reported
Any other information on results incl. tables
Based on the calculation during the preliminary test, the log Pow of RED 0106-PP1 was estimated to above 2.1. Therefore the HPLC-method was chosen to conduct the main test. Six common standards, which have known log Pow values in the range of 1.6 to 5.7, were used as reference standards during the main test. The RED 0106-PP1 solution was injected three times and the combined reference item solution was injected six times. The log Pow was calculated using a regression curve (log k' vs. log Pow) and was found to be 2.7. The chromatography of the test item resulted in one sharp main peak with a well defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, RED 0106-PP1 was considered to be stable during the test procedure.
Applicant's summary and conclusion
- Conclusions:
- Log Pow = 2.7
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