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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
2004
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Acid Navy RN-2682
IUPAC Name:
Acid Navy RN-2682
Test material form:
solid

Study design

Analytical monitoring:
yes
Buffers:
pH 4, 7, 9
Details on test conditions:
According to the guideline, a preliminary test was performed at 50 °C ± 0.5 °C at each of pH 4.0, pH 7.0 and pH 9.0. Aliquots of each test solution were analyzed in time intervals using the analytical method as described later in this report. Analysis was performed before incubation, after 2.4 hours and after 120 hours.
A main study was not required, as the test item was found to be stable according to the criteria given in the guideline.
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
ca. 121 - 122 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
ca. 105 - 108 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
ca. 92 mg/L

Results and discussion

Preliminary study:
The results of pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of test item at 50 °C. The degradation of test item was less than 10% after 5 days.
It can be concluded, that the estimated halfl-ife time is higher than one year under representative environmental conditions (25 °C).
Hydrolytically stable, and no further testing was necessary.
Transformation products:
no
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Remarks on result:
hydrolytically stable based on preliminary test
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Remarks on result:
hydrolytically stable based on preliminary test
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Remarks on result:
hydrolytically stable based on preliminary test

Applicant's summary and conclusion

Conclusions:
Hydrolytically stable; no further testing was necessary.