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Diss Factsheets
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EC number: 481-730-0 | CAS number: 848301-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer reviewed international scientific journal
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Health assessment of gasoline and fuel oxygenate vapors: Neurotoxicity evaluation
- Author:
- J.P. O’Callaghan et al.
- Year:
- 2 014
- Bibliographic source:
- Regulatory Toxicology and Pharmacology (2014; in press). doi: 10.1016/j.yrtph.2014.05.002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.6200 (Neurotoxicity Screening Battery)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: EPA GFAP determination (GFAP Assay 79.67, CFR Vol. 59, No. 122, 27 June 1994)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Baseline gasoline vapor condensate
- IUPAC Name:
- Baseline gasoline vapor condensate
- Details on test material:
- - Name of test material (as cited in study report): Baseline gasoline vapor condensate (BGVC)
- Composition of test material, percentage of components: see below "Any other information on materials and methods incl. tables", Tables 1 and 2
- Other: Test substance is closely related to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear', but it contains a higher level of aromatics, olefins and cycloparaffins. It can be assumed that the level of toxicity of 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear', mainly consisting of branched and linear hydrocarbons is, however, considerably less (or at least the same) than that seen with the test material.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 6 h/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 2000, 10000, 20000 mg/m3/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes, concurrent vehicle
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Overall, administration of the gasoline substances at the concentrations tested were not associated with changes in motor activity or with any change in counts of the 25 nominal FOB measures, or the 4 continuous FOB measures.
All substances (and consequently, the closely related test material ‘Baseline gasoline vapor condensate'’ (BGVC) as well) showed no statistically significant increases in GFAP (Glial Fibrillary Acidic Protein) levels in male or female rats. Under the exposure conditions employed, treatmentinduced astrogliosis i.e. an induction in brain region levels of GFAP, did not occur in the representative areas of the adult rat brain. - Executive summary:
Sprague–Dawley rats were exposed via inhalation to vapor condensates of either gasoline or gasoline combined with various fuel oxygenates to assess potential neurotoxicity of evaporative emissions. Test articles included vapor condensates prepared from ‘‘baseline gasoline’’ (BGVC), or gasoline combined with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA). Target concentrations were 0, 2000, 10,000 or 20,000 mg/mg3 and exposures were for 6 h/day, 5 days/week for 13 weeks. The functional observation battery (FOB) with the addition of motor activity (MA) testing, hematoxylin and eosin
staining of brain tissue sections, and brain regional analysis of glial fibrillary acidic protein (GFAP) were used to assess behavioral changes, traditional neuropathology and astrogliosis, respectively.
Functional observation battery (FOB) and motor activity (MA) data for all agents, except G/TBA, were negative. G/TBA behavioral effects resolved during recovery. Neuropathology was negative for all groups. Analyses of GFAP revealed increases in multiplebrain regions largely limited to males of the G/EtOH group, findings indicative of minor gliosis, most significantly in the cerebellum. Small changes (both increases and decreases) in GFAP (Glial Fibrillary Acidic Protein) were observed for other test agents but effects were not consistent across sex, brain region or exposure concentration.
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