Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 475-670-4 | CAS number: 120100-05-2
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- Test procedure:
OECD 429
Results and discussion
- Details on results:
- The results show that the test item (AE 0761014) has a
sensitizing potential in mice after dermal application.
Compared to vehicle treated animals there was a clear
increase regarding the weights of the draining lymph nodes
which is of statistical significance in the mid and the
high dose group and a clear increase in the cell counts in
all dose groups. These changes are of statistical
significance. The "positive level" of index 1.4 was exceeded
for the cell counts in all dose groups.
A significant increase compared to vehicle treated animals
regarding ear swelling was detected in the high dose group
and for ear weights in the mid and the high dose group. An
increase in this parameter do point to an acute irritating
(inflammatory) response. However, such an irritating
property is also combined with a strong skin sensitizing
potential of a test compound.
The results show that the test item has a sensitizing
potential in mice after dermal application.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
