Registration Dossier
Registration Dossier
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EC number: 464-390-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD No.402 (1987) "Acute Dermal Toxicity" EC, Council Directive 67/548/EEC, Annex V, B.3 (1992) "Acute Toxicity (Dermal)" EPA, OPPTS 870.1200 (1998), "Acute Dermal Toxicity" JMAFF Guidelines (2000), including the most recent revisions.
- GLP compliance:
- yes
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- other: Rat, Wistar starin Crl:(WI)BR
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Milli-U water.
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Ptosis or chromodacryorrhoea was observed among some animals on days 1 and/or 2.
- Gross pathology:
- Effects on organs:
No abnormalities were found at macroscopic post mortem
examination of the animals. - Other findings:
- Signs of toxicity (local):
Purple staining of the treated skin, neck and/or back was
observed among all animals during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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