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EC number: 801-277-8 | CAS number: 507448-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
- EC Number:
- 801-277-8
- Cas Number:
- 507448-65-9
- Molecular formula:
- C7H10F3NO2
- IUPAC Name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
Citrate buffer pH 4.0 20 mM sodium citrate
Phosphate buffer pH 7.0 20 mM sodium phosphate
Borax buffer pH 9.0 20 mM sodium tetraborate
Results and discussion
- Details on results:
Results for pH 4 buffer and pH 7 buffer solutions
The half-life time of CA 2455 in the pH 4 buffer solution and in the pH7 buffer solution was estimated from the results of the preliminary test to be less than one day at 25 °C and, consequently, must also be less than one day at 20 °C. The final pH values from these experiments were determined to be 4.0 and 7.2 respectively.
Arrhenius Fit – Extrapolation to 25 °C and 20 °C for pH 0
Using the Arrhenius equation, a plot of the logarithm of kobs, determined at 50.0 °C, 40.0 °C and 30.0 °C versus the reciprocal of the temperature (in kelvin) was made.
Refer to Table 1
Substitution of 25.0 °C and 20.0 °C (as the reciprocal of the absolute temperature) in the Arrhenius equation yielded the log k values at these two temperatures.
Summary of Results
Temperature (°C) 25.0 20.0
k obs 0.005047 hours -1 0.002974 hours -1
t ½ 137 hours 233 hours
t ½ 5.72 days 9.71 days
For Graphical Presentation of the Arrhenius Extrapolation to 25 °C and 20 °C for pH9 refer to CA 2455 Figure 1.
Any other information on results incl. tables
Table 1
Hydrolysis Solution |
Rate Constant (hours-1) |
Log rate Constant (hours-1) |
Temperature |
||
|
Individual |
Average |
|
1/K |
°C |
H93 H94
H95 H96
H97 H98
|
0.056803 0.056018
0.021692 0.021719
0.008590 0.008470
|
0.056411
0.021706
0.008530 |
-1.2486
-1.6634
-2.0691 |
0.003095
0.003193
0.003299 |
50.0
40.0
30.0 |
Applicant's summary and conclusion
- Conclusions:
The rate of hydrolysis of CA 2455 has been determined at three pH values.
The half-life times (t½) of the test substance were determined either by extrapolation of the experimental values (for buffer solutions pH 9.0) or by estimation from the preliminary test (buffer solutions pH 4.0 and pH 7.0).
Half-life times (t½)
Buffer solution At 20°C At 25° C
pH 4.0 < 1 day < 1day
pH 7.2 < 1 day < 1day
pH 9.2 233 hours 137 hours
These results have been quoted to three significant figures, where appropriate.- Executive summary:
The rate of hydrolysis of CA 2455 has been determined at three pH values.
The half-life times (t½) of the test substance were determined either by extrapolation of the experimental values (for buffer solutions pH 9.0) or by estimation from the preliminary test (buffer solutions pH 4.0 and pH 7.0).
Half-life times (t½)
Buffer solution
At 20°C
At 25° C
pH 4.0
< 1 day
< 1day
pH 7.2
< 1 day
< 1day
pH 9.2
233 hours
137 hours
These results have been quoted to three significant figures, where appropriate.
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