Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 286-081-5 | CAS number: 85186-95-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h): ≥ 1000 mg/L for the respiration of activated sludge microorganisms (OECD 209); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Fatty acids, C12-16, esters with neopentyl glycol (CAS No. 85186-95-4) to microorganisms. The assessment was, therefore, based on a study conducted with the structurally similar category member heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5), as part of a read-across approach. This approach is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across. Further justification is given within the endpoint summary in IUCLID chapter 6.1 and within the category justification in IUCLID section 13.
The key study conducted with heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed as according to the OECD Guideline 209 and GLP (Roulstone, 2012). Activated sludge of a predominantly domestic sewage was exposed to the nominal test concentrations of 10, 100 and 1000 mg/L for 3 hours. No inhibition of the respiration rate of the activated sludge was observed. The respiration rate increased in all treatments, compared to the controls. The NOEC (3 h) was reported to be≥1000 mg/L.
Additionally, Fatty acids, C12-16, esters with neopentyl glycol is readily biodegradable (90.2% biodegradation in 28 days), which implies low toxicity to activated sludge microorganisms.
Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as explained with in the overall endpoint summary in IUCLID chapter 6.1, it can be concluded that the toxicity of Fatty acids, C12-16, esters with neopentyl glycol to aquatic microorganisms is very low. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results within the polyol esters category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
