Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: data from ECHA database
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
other: New Zealand hybrid albino rabbit

Test system

Type of coverage:
semiocclusive
Vehicle:
other: Sterile Codex liquid paraffin
Amount / concentration applied:
46 mg
Duration of treatment / exposure:
4 h
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Score:
0.3
Max. score:
2
Remarks on result:
other: Max. duration: 48d; Max. value at end of observation period: 0
Irritation parameter:
edema score
Basis:
mean
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0d; Max. value at end of observation period: 0
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fullly reversible within 3 days

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information