Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The avaiilable acute oral toxicity values ranged between 250 mg/kg bw and > 2000 mg/kg bw for the primary constituents of GLS-Silane (dichloro(methyl)silane - CAS 75-54-7; tetramethylsilane - CAS 75-76-3; trichlorosilane - CAS 10025-78-2; and 2-methylbutane - CAS 78-78-4).  Thus, the mid-point value for the primary constituents of GLS-Silane for which acute oral toxicity values were available was 1320 mg/kg bw.  

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 320 mg/kg bw

Additional information

According to the CLP, the test substance is classified as Acute Oral Category 4, "Harmful if swallowed" and Acute Inhalation Category 4, "Harmful if inhaled". This is based on: vapour inhalation (4 hour) 10.0 < LC50 </= 20 mg/L, and 300 < oral LD50 </= 2000 mg/kg bw.

Justification for classification or non-classification