Registration Dossier
Registration Dossier
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EC number: 606-280-6 | CAS number: 192704-54-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Sep to Oct 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well reported Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-Cyano-11 alpha-hydroxy-3,5'-dioxo-4 beta,5',6,7 beta-tetrahydrocyclopenta[4,5,6,7]-5 beta,17 alpha-pregnane-21,17-carbolactone
- EC Number:
- 606-280-6
- Cas Number:
- 192704-54-4
- Molecular formula:
- C24 H29 N O5
- IUPAC Name:
- 5-Cyano-11 alpha-hydroxy-3,5'-dioxo-4 beta,5',6,7 beta-tetrahydrocyclopenta[4,5,6,7]-5 beta,17 alpha-pregnane-21,17-carbolactone
- Details on test material:
- - Name of test material (as cited in study report): ZK 233744
- Batch No.: 1366
- Purity: 92.3%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: physiol. saline + Myrj 53 in bidest.water
- Doses:
- 2000 mg/kg (application volume 10 mL/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No animal died in the course of the study. No compound-related clinical signs, effects on body weight or abnormalities at necropsy were observed.
Applicant's summary and conclusion
- Executive summary:
The single oral administration of the test substance (ZK 233744) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs or effects on body weight were observed and there were no macroscopic pathological signs.
The acute oral toxicity of Diketon in rats is therefore above 2000 mg/kg body weight.
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