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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study under GLP with minor deviations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Principles of method if other than guideline:
concentration factor = 10
highest concentration = 500 mg/l
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Octylamine
EC Number:
203-916-0
EC Name:
Octylamine
Cas Number:
111-86-4
Molecular formula:
C8H19N
IUPAC Name:
octan-1-amine

Sampling and analysis

Details on sampling:
Before filling into test bassins under continous stirring the test substance was mixed with dilution water and homogenized by Ultra-Turrax.


Testing approach was as a solution to turbidity. At all concentrations tested
no segregation could be observed from the ground and educational bodies.


10 - 100 mg / l, the pH value after the substance was added at 8.6 to 11.5. he was
adjusted with 1N HCl to the pH of the water test.

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Test temperature:
22±1°C
pH:
8-8.2
Dissolved oxygen:
≥80% of the saturation value
Nominal and measured concentrations:
0 / 1 / 10 / 100 und 500 mg/l
Details on test conditions:
The experiment was carried out in 2 parts. Per experimental group 10 fish were used.
1. test: concentrations: 0 + 500 mg/l
2. test: concentrations 0 / 1 / 10 / 100 mg/l

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
10 - 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
10 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Conclusions:
The LC50 (96h) to fish (Danio rerio) according to OECD203 study of the substance is in the range of 10-100 mg/l.
Executive summary:

The LC50 (96h) to fish (Danio rerio) according to OECD203 study of the substance is in the range of 10-100 mg/l.