Registration Dossier
Registration Dossier
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EC number: 480-420-2 | CAS number: 144702-27-2
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 January - 24 January 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and in accordance with several internationally established guidelines (OECD, EEC, EPA, see below).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- capillary method
Test material
- Reference substance name:
- -
- EC Number:
- 480-420-2
- EC Name:
- -
- Cas Number:
- 144702-27-2
- Molecular formula:
- C33 H29 N5
- IUPAC Name:
- 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carbonitrile
- Details on test material:
- - Name of test material (as cited in study report): BIBR 277 Nitril
- Molecular formula (if other than submission substance): C33H29N5
- Molecular weight (if other than submission substance): 495.6 g/mol
- Structural formula attached as image file (if other than submission substance): see reference substance
- Physical state: solid; slight yellowish
- Analytical purity: 99.7 %
- Purity test date: 17. october 2005
- Lot/batch No.: T02/03
- Expiration date of the lot/batch: april 2006
- Storage condition of test material: at room temperature, dark and dry
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- 197.3 °C
- Atm. press.:
- 1 013 mBar
- Remarks on result:
- other: atmospheric pressure assumed
Any other information on results incl. tables
table 1 summary of results from measurements I, II and III
| measured temperature [°C] | |||
| Measurement | I/1 | I/2 | I/3 |
| Melting point | 197.3 | 197.3 | 197.3 |
| Measurement | II/1 | II/2 | II/3 |
| Melting point | 197.4 | 197.4 | 197.4 |
| Measurement | III/1 | III/2 | III/3 |
| Melting point | 197.3 | 197.3 | 197.3 |
| Mean value | |||
| Mean value | 197.3 +/-0.04 | ||
Applicant's summary and conclusion
- Conclusions:
- A melting temperature value of 197.3 °C was determined in a reliable study conducted according to a appropriate test protocol and in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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