Registration Dossier
Registration Dossier
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EC number: 923-418-3 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Remarks:
- Calculated with EPI suite KOWWIN
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- LCE08121
- IUPAC Name:
- LCE08121
- Details on test material:
- Test ITEM : LCE08121
Description of the product : Acetalization products between glucose and C14 alcohol
It is a co-emulsifier for oil-in-water emulsions in cosmetic formulas.
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.13
- Temp.:
- 20.2 °C
- pH:
- 6.5
- Details on results:
- none
Applicant's summary and conclusion
- Conclusions:
- The value of partition coefficient found for the test item LCE08121 is :
Pow = 1.34 E+03 and Log(Pow) = 3.13 at 20.2°C in purified water (pH 6.5). - Executive summary:
This study consisted in the determination of the partition coefficient of one batch of LCE08121 referenced as batch N° T82925.
The sdudy follow the n°107 guideline of the OECD and has been realized according to the GLP principle.
Principle of the method
The test was run according to the "Shake Flask Method" as described in EEC Method A8, in OECD guidelines for the testing of chemicals, method 107.
Outline of method
The test item is diluted into octanol saturated with water. This solution is diluted with different amounts of n-octanol saturated in water to prepare the test solutions.
After the phase separation, the concentration of the test item in the n-octanol phase (Co) and in the aqueous phase (Cw) is determined by HPLC analysis.
The partition coefficient (Pow) is calculated as the ratio between the two concentrations :
Pow= Co/Cw
Results
see test results sheet.
Conclusion
The value of partition coefficient found for the test item LCE08121 is :
Pow = 1.34 E+03 and Log(Pow) = 3.13 at 20.2°C in purified water (pH 6.5).
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