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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The data source is the competent authority, it is considered reliable. Although details on test method and results are not completely described, the results are sufficient to aim
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Principles of method if other than guideline:
Test was conducted on white mice and rats at dose from 3 to 15 g/kg.
During the acute experiment dynamic monitoring of the clinical signs was carried out and the weight of animals was measured.
GLP compliance:
not specified
Test type:
other: not reported
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,2-trichloro-1,2-difluoroethane
EC Number:
940-543-9
Cas Number:
354-15-4
Molecular formula:
C2HCl3F2
IUPAC Name:
1,1,2-trichloro-1,2-difluoroethane
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F



Test animals

Species:
other: rat and mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
from 3 to 15 g/kg
No. of animals per sex per dose:
not reported
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
8 680 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
HCFC 122a is a low-toxic compound, experimental results were very closed to the predicted LD50 value of 8680 mg/kg.
Executive summary:

The objective of the reported study was to investigate the toxicity of HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed.

 

The acute toxicity levels of the HCFC 122a were both calculated and experimentally determined.

 

In order to obtain approximate data on the acute toxicity of the HCFC 122a and HCFC 132, the following equation, derived basing on experimental data on similar compounds, was applied:

log LD50(mmol/kg) = 1.25 – 1.54 · tb· 10-2+ 0.63 · log Pow

where:

tb= boiling point

Pow = partition coefficient octanol/water

 

The calculated value of LD50for HCFC 122a is reported to be 8680 mg/kg b.w.

Following the calculation of the approximated LD50, experimental studies of oral acute toxicity were conducted on white mice and rats at dose from 3 to 15 g/kg.

During the acute experiment dynamic monitoring of the clinical sign was carried out and the weight of animals was measured.

Results show that HCFC 122a is a low-toxic compound, since the experimental results were very closed to the predicted toxicity parameters.

Clinical signs in animals predominantly consisted of symptoms of nervous system damage. Acute poisoning within the first hours was accompanied by excitation of animals, followed by depression, motor retardation, shortness of breath, muscle atonia. Death of laboratory animals was observed within the first 1-3 days of observations. No species-sensitivity was observed. HCFC 122a and HCFC 132 did not exhibit cumulative properties.