Ethane, 1,1,2-trichloro-1,2-difluoro-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

The data source is the competent authority. Although details on test method and results are not completely described, the results are sufficient to assess acute hazard.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Materials and methods

Principles of method if other than guideline:

Test was conducted on white mice and rats at dose from 3 to 15 g/kg.
During the acute experiment dynamic monitoring of the clinical signs was carried out and the weight of animals was measured.

GLP compliance:

not specified

Test type:

other: not reported

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2-trichloro-1,2-difluoroethane

EC Number:

940-543-9

Cas Number:

354-15-4

Molecular formula:

C2HCl3F2

IUPAC Name:

1,1,2-trichloro-1,2-difluoroethane

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F

Test animals

Species:

other: rat and mouse

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

from 3 to 15 g/kg

No. of animals per sex per dose:

not reported

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

approximate LD50

Effect level:

8 680 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

HCFC 122a is a low-toxic compound, experimental results were very close to the predicted LD50 value of 8680 mg/kg.

Executive summary:

The objective of the reported study was to investigate the toxicity of HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed.

 

The acute toxicity levels of the HCFC 122a were both calculated and experimentally determined.

 

In order to obtain approximate data on the acute toxicity of the HCFC 122a and HCFC 132, the following equation, derived basing on experimental data on similar compounds, was applied:

log LD₅₀(mmol/kg) = 1.25 – 1.54 · t_b· 10^-2+ 0.63 · log Pow

where:

t_b= boiling point

Pow = partition coefficient octanol/water

 

The calculated value of LD₅₀for HCFC 122a is reported to be 8680 mg/kg b.w.

 

Following the calculation of the approximated LD₅₀, experimental studies of oral acute toxicity were conducted on white mice and rats at doses ranging from 3 to 15 g/kg.

During the acute experiment dynamic monitoring of the clinical sign was carried out and the weight of animals was measured.

Results show that HCFC 122a is a low-toxic compound, and the experimental results were very close to the predicted toxicity parameters.

Clinical signs in animals predominantly consisted of symptoms of nervous system damage. Acute poisoning within the first hours was accompanied by excitation of animals, followed by depression, motor retardation, shortness of breath, muscle atonia. Death of laboratory animals was observed within the first 1-3 days of observations. No species-sensitivity was observed. HCFC 122a and HCFC 132 did not exhibit cumulative properties.