Registration Dossier
Registration Dossier
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EC number: 237-324-9 | CAS number: 13746-89-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non guideline and non GLP study. Basic data given. Limitations in design and reporting.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect on the organism of rare, dispersed, and other metals, and their compounds used in industry: zirconium
- Author:
- Mogilevskaya, O. Ya.
- Year:
- 1 968
- Bibliographic source:
- National Science Foundation: Toxicology of rare metals, Washington D.C., 1967, pg 44
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Only five animals per dose were exposed two to three times to the dust of zirconium.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zirconium
- EC Number:
- 231-176-9
- EC Name:
- Zirconium
- Cas Number:
- 7440-67-7
- IUPAC Name:
- zirconium(2+)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Details on inhalation exposure:
- Test substance was applied two or three times.
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- no data
- Concentrations:
- 2 - 3 mg/L
- No. of animals per sex per dose:
- 5 animals per dose
- Control animals:
- yes
- Details on study design:
- - Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: concentration of Zr
- Effect level:
- > 2 - <= 3 mg/L air
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No clinical signs of toxicity were observed.
- Body weight:
- No data
- Gross pathology:
- Histological examinations of the organs did not reveal any treatment-related findings. In the lungs considerable pulmonary congestions were detected.
Applicant's summary and conclusion
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