Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Study does not need to be conducted according to REACH Annex VIII 8.7.1 because information from teratogenicity studies and repeated dose studies are available. Since significant scientific evidence for a lack of reprotoxic effects of the substance is drawn from these results and an additional two generation study is not expected to add any further relevant knowledge on this endpoint. Due to animal welfare aspects and/or laws, an additional study is therefore not warranted.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 150 mg/kg bw/day
Additional information
NOAEL
for maternal toxicity: Administration of
4,6-bis(octylthiomethyl)-o-cresol during gestation by oral gavage at a
dose level of 300 mg/kg elicited slight maternal toxicity (slightly
reduced body weight gain and - possibly - slightly reduced food
consumption), but no embryotoxicity, and no teratogenicity.
Administration of 50 and 150 mg/kg did not elicit any maternal toxicity,
embryotoxicity, or teratogenicity
Justification for classification or non-classification
Based on the results there is a significant scientific evidence for a lack of reprotoxic effects of 4,6-bis(octylthiomethyl)-o-cresol and an additional two generation study is not expected to add any further relevant knowledge on this endpoint. Due to animal welfare aspects and/or laws, an additional study is therefore not warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
